April 29, 2017
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Cephalexin

Medical and Pharmacy Editor:

Brand Name: Keflex, Panixine Disperdose

Generic Name: cephalexin

Drug Class: Cephalosporins, 1st Generation

What Is Cephalexin and How Does It Work?

Cephalexin is used to treat a wide variety of bacterial infections. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria.

Cephalexin will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

Cephalexin is available under the following different brand names: Keflex, and Panixine Disperdose.

Dosages of Cephalexin:

Adult and Pediatric Dosage Forms and Strengths

Capsule

  • 250 mg
  • 500 mg
  • 750 mg (adult only)

Oral suspension

  • 125 mg/5mL
  • 250 mg/5mL

Tablet

  • 125 mg (pediatric only)
  • 250 mg
  • 500 mg (adult only)

Dosage Considerations – Should be Given as Follows:

Genitourinary Tract Infections

  • Adult: 250 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses
  • Pediatric: 25-50 mg/kg/day orally divided every 6-8 hours for 10 days; not to exceed 4 g/day

Bone Infections

  • Adult: 250 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses
  • Pediatric: 25-50 mg/kg/day orally divided every 6-8 hours for 10 days; not to exceed 4 g/day

Uncomplicated Cystitis

  • Adult: 250 mg orally every 6 hours or 500 mg orally every 12 hours; dosage range, 1-4 g/day in divided doses
  • Younger than 15 years: 25-50 mg/kg/day orally divided every 6-8 hours for 10 days; not to exceed 4 g/day
  • Children older than 15 years: 250 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses

Otitis Media

  • Adult: 250 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses
  • Pediatric: 75-100 mg/kg/day orally divided every 6 hours for 10 days; not to exceed 4 g/day

Skin/Skin Structure Infections

  • Adult: 250 mg orally every 6 hours or 500 mg orally every 12 hours; dosage range, 1-4 g/day in divided doses
  • Pediatric: 25-50 mg/kg/day orally divided every 6-8 hours for 10 days; not to exceed 4 g/day

Respiratory Tract Infections

  • Adult: 250 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses
  • Pediatric: 25-50 mg/kg/day orally divided every 6-8 hours for 10 days; not to exceed 4 g/day

Streptococcal Pharyngitis

  • Adult: 250 mg orally every 6 hours or 500 mg orally every 12 hours; dosage range, 1-4 g/day in divided doses
  • Pediatric: 25-50 mg/kg orally every 12 hours for 10 days; not to exceed 500 mg every 12 hours

Cellulitis and Mastitis

  • Adult: 500 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses
  • Adolescents: 500 mg orally every 6 hours; dosage range, 1-4 g/day in divided doses

Renal Impairment

  • CrCl less than 10 mL/min: 250-500 mg orally every 12-24 hours
  • CrCl 10-50 mL/min: 500 mg orally every 8-12 hours

Beta-Hemolytic Streptococcal Infections, Pediatric

  • 25-50 mg/kg/day orally divided every 6-8 hours for 10 days; not to exceed 4 g/days

Hepatic Impairment

  • Not studied

Dosing Considerations

Susceptible organisms

Medically Reviewed by a Doctor on 4/18/2017



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