April 28, 2017
Recommended Topic Related To:


"About 1 out of 10 people has had a seizure. Do you know what to do if someone has a seizure near you? Read below to learn more.

About 1 out of 10 people has had a seizure. That means seizures are common, and one day you might need to help s"...



Cerebyx Patient Information including If I Miss a Dose

What happens if I miss a dose (Cerebyx)?

Call your doctor for instructions if you miss a dose of fosphenytoin.

What happens if I overdose (Cerebyx)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of fosphenytoin can be fatal.

Overdose symptoms may include weakness, nausea, vomiting, feeling light-headed, chest pain, fast or slow heart rate, weak pulse, slow breathing (breathing may stop).

What should I avoid while using fosphenytoin (Cerebyx)?

Avoid drinking alcohol while you are receiving fosphenytoin. Alcohol use can increase your blood levels of fosphenytoin and may increase side effects. Daily alcohol use can decrease your blood levels of fosphenytoin, which can increase your risk of seizures.

What other drugs will affect fosphenytoin (Cerebyx)?

Drugs that can increase fosphenytoin levels in your blood include:

  • amiodarone (Cordarone, Pacerone);
  • disulfiram (Antabuse);
  • fluorouracil (5FU, Adrucil);
  • ethosuximide (Zarontin);
  • isoniazid (for treating tuberculosis);
  • methylphenidate (Ritalin, Concerta, Daytrana);
  • tolbutamide (Orinase);
  • birth control pills or hormone replacement therapy;
  • chlorpromazine (Thorazine), prochlorperazine (Compazine, Compro), promethazine (Pentazine, Phenergan, Anergan, Antinaus), thioridazine (Mellaril), and other phenothiazines;
  • phenobarbital (Solfoton) or other barbiturates;
  • salicylates such as aspirin, Backache Relief Extra Strength, Novasal, Nuprin Backache Caplet, Doan's Pills Extra Strength, Pepto-Bismol, Tricosal, and others;
  • stomach acid reducers such as cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), or nizatidine (Axid);
  • certain sedatives (such as Librium, Librax, Limbitrol, or Valium) or antidepressants such as fluoxetine (Prozac, Rapiflux, Sarafem, Selfemra, Symbyax) or trazodone (Desyrel); or
  • sulfa drugs (Bactrim, Septra, Sulfatrim, SMX-TMP, and others).

Drugs that can make fosphenytoin less effective in controlling seizures include:

  • reserpine; or
  • carbamazepine (Carbatrol, Equetro, Tegretol).

Other drugs that can interact with fosphenytoin include:

  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • digoxin (digitalis, Lanoxin);
  • furosemide (Lasix);
  • steroid medications (prednisone and others);
  • theophylline (Elixophyllin, Theo-Dur, Theo-Bid, Theolair, Uniphyl);
  • valproic acid (Depakene) or divalproex sodium (Depakote);
  • an antibiotic such as rifampin (Rimactane, Rifadin, Rifamate) or doxycycline (Doryx, Vibramycin, Adoxa, and others); or
  • an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others.

This list is not complete and there are many other medicines that can interact with fosphenytoin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without your doctor's advice.

Where can I get more information?

Your pharmacist can provide more information about fosphenytoin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2013 Cerner Multum, Inc. Version: 2.01. Revision date: 1/15/2012.

Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.


Side Effects Centers

Report Problems to the Food and Drug Administration


You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Find tips and treatments to control seizures.