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Experience in over 1000 patients treated with Ceredase® (alglucerase injection) has revealed a small number of adverse events. Some of these events were related to the route of administration including discomfort, pruritus, burning and swelling or sterile abscess at the site of venipuncture. The remaining experiences consisted of slight fever, chills, abdominal discomfort, nausea or vomiting. None of these events were judged to require medical intervention.
Symptoms suggestive of hypersensitivity have been noted in a limited number of patients. Onset of such symptoms has occurred during or shortly after infusions; these symptoms have included pruritus, flushing, urticaria/angioedema (a small number of patients have had upper airway involvement), chest discomfort, respiratory symptoms, nausea and abdominal cramping. Hypotension has been reported to occur during a few of these events. (See WARNINGS.)
Pretreatment with antihistamines and reduced rate of infusion has allowed continued use of Ceredase® (alglucerase injection) in most patients. Additional adverse symptoms which have been reported include: fatigue, vasomotor irritability or hot flash, weakness, headache, light headedness, dysosmia, oral ulcerations, backache and transient peripheral edema, and diarrhea. Menstrual abnormalities and false positive pregnancy tests have previously been reported, but due to the introduction of manufacturing steps designed to reduce the level of hCG in Ceredase® (alglucerase injection) , the likelihood of these occurrences is reduced.
Read the Ceredase (alglucerase injection) Side Effects Center for a complete guide to possible side effects
No information provided.
Last reviewed on RxList: 1/28/2009
This monograph has been modified to include the generic and brand name in many instances.
Additional Ceredase Information
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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