"The U.S. Food and Drug Administration today approved a new use of Gleevec (imatinib) to treat children newly diagnosed with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL).
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Dose-limiting toxicity includes myelosuppression and cardiotoxicity (See WARNINGS). Other reactions include:
Gastrointestinal:Acute nausea and vomiting occur but are usually mild. Antiemetic therapy may be of some help. Mucositis may occur 3 to 7 days after administration. Diarrhea and abdominal pain have occasionally been reported.
Read the Cerubidine (daunorubicin) Side Effects Center for a complete guide to possible side effects
Use of Cerubidine (daunorubicin) in a patient who has previously received doxorubicin increases the risk of cardiotoxicity. Cerubidine (daunorubicin) should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or Cerubidine (daunorubicin) . Cyclophosphamide used concurrently with Cerubidine (daunorubicin) may also result in increased cardiotoxicity. Dosage reduction of Cerubidine (daunorubicin) may be required when used concurrently with other myelosup-pressive agents.
Hepatotoxic medications, such as high-dose methotrexate, may impair liver function and increase the risk of toxicity.
Read the Cerubidine Drug Interactions Center for a complete guide to possible interactions
Last reviewed on RxList: 8/13/2008
This monograph has been modified to include the generic and brand name in many instances.
Additional Cerubidine Information
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