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Cerubidine

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Cerubidine

Side Effects
Interactions

SIDE EFFECTS

Dose-limiting toxicity includes myelosuppression and cardiotoxicity (See WARNINGS). Other reactions include:

Cutaneous: Reversible alopecia occurs in most patients. Rash, contact dermatitis and urticaria have occurred rarely.

Gastrointestinal:Acute nausea and vomiting occur but are usually mild. Antiemetic therapy may be of some help. Mucositis may occur 3 to 7 days after administration. Diarrhea and abdominal pain have occasionally been reported.

Local: If extravasation occurs during administration, severe local tissue necrosis, severe celluli-tis, thrombophlebitis, or painful induration can result.

Acute Reactions: Rarely, anaphylactoid reaction, fever, and chills can occur. Hyperuricemia may occur, especially in patients with leukemia, and serum uric acid levels should be monitored.

Read the Cerubidine (daunorubicin) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Use of Cerubidine (daunorubicin) in a patient who has previously received doxorubicin increases the risk of cardiotoxicity. Cerubidine (daunorubicin) should not be used in patients who have previously received the recommended maximum cumulative doses of doxorubicin or Cerubidine (daunorubicin) . Cyclophosphamide used concurrently with Cerubidine (daunorubicin) may also result in increased cardiotoxicity. Dosage reduction of Cerubidine (daunorubicin) may be required when used concurrently with other myelosup-pressive agents.

Hepatotoxic medications, such as high-dose methotrexate, may impair liver function and increase the risk of toxicity.

Read the Cerubidine Drug Interactions Center for a complete guide to possible interactions

Last reviewed on RxList: 8/13/2008
This monograph has been modified to include the generic and brand name in many instances.

Side Effects
Interactions
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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