Cervidil (Dinoprostone) Drug Information: Description, User Reviews, Drug Side Effects, Interactions

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May 26, 2012

Cervidil

Pregnancy (Stages - Trimesters of Pregnancy) »

Pregnancy facts*

*Pregnancy facts Medically Edited by: Melissa Conrad Stöppler, MD

A normal pregnancy lasts about 40 weeks and is grouped into three trimesters.
Symptoms of early pregnancy include the absence of menstrual periods, breast changes, tiredness, nausea, mood swings, or other symptoms.
A pregnancy test measures the hormone human chorionic gonadotropin in the urine or blood.
Symptoms of late pregnancy can include heartburn, difficulty sleeping, swelling of the ankles or fingers, hemorrhoids, and mild contractions.
By the end of 37 weeks, a baby is considered full term and its organs are ready to function on their own.
As you near your due date, your baby may turn into a head-down position for birth. Most babies "present" head down.
Babies at birth typically weigh between 6 pounds 2 ounces and 9 pounds 2 ounces and are 19 to 21 inches long. M...

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Cervidil

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CERVIDIL®
(dinoprostone) Vaginal Insert

DRUG DESCRIPTION

Dinoprostone vaginal insert is a thin, flat, polymeric slab which is rectangular in shape with rounded corners contained within the pouch of an off-white knitted polyester retrieval system. Each slab is buff colored, semitransparent and contains 10 mg of dinoprostone in a hydrogel insert. An integral part of the knitted polyester retrieval system is a long tape designed to aid retrieval at the end of the dosing interval or earlier if clinically indicated. The finished product is a controlled release formulation which has been found to release dinoprostone in vivo at a rate of approximately 0.3 mg/hr.

The chemical name for dinoprostone (commonly known as prostaglandin E₂ or PGE₂) is 11α, 15S-dihydroxy-9-oxo-prosta-5Z,13E-dien-1-oic acid and the structural formula is represented below:

CERVIDIL®
(dinoprostone) Structural Formula Illustration

The molecular formula is C₂₀H₃₂O₅ and its molecular weight is 352.5. Dinoprostone occurs as a white to off-white crystalline powder. It has a melting point within the range of 65° to 69°C. Dinoprostone is soluble in ethanol and in 25% ethanol in water. Each insert contains 10 mg of dinoprostone in 241 mg of a cross-linked polyethylene oxide/urethane polymer which is a semi-opaque, beige colored, flat rectangular slab measuring 29 mm by 9.5 mm and 0.8 mm in thickness. The insert and its retrieval system, made of polyester yarn, are non-toxic and when placed in a moist environment, absorb water, swell, and release dinoprostone.

What are the possible side effects of dinoprostone topical (Cervidil, Prepidil, Prostin E2)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if your contractions slow down or become uneven, if you feel like you have a fever, or if you have any sudden vaginal bleeding.

Less serious side effects may include:

nausea, stomach pain;
back pain; or
feeling of warmth in the vaginal area.

This is not a...

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What are the precautions when taking dinoprostone (Cervidil)?

Before using dinoprostone, tell your doctor, midwife, or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this drug, tell your doctor your medical history, including: asthma, full term births including previous cesarean section (c-section) births, glaucoma, infections in the vaginal area (e.g., genital herpes), surgery on the cervix, surgery on the womb (uterus), vaginal bleeding during pregnancy, womb scarring.

This drug should not be used if you are carrying more than one baby, if your labor has already started, or if your water has broken.

This medication should be used only when...

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Last reviewed on RxList: 6/17/2010
This monograph has been modified to include the generic and brand name in many instances.