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Cesamet® (nabilone) is a synthetic cannabinoid for oral administration. Nabilone as a raw material occurs as a white to off-white polymorphic crystalline powder. In aqueous media, the solubility of nabilone is less than 0.5 mg/L, with pH values ranging from 1.2 to 7.0.
Chemically, nabilone is similar to the active ingredient found in naturally occurring Cannabis sativa L. [Marijuana; delta-9-tetrahydrocannabinol (delta-9-THC)]. Nabilone is (±)-trans-3-(l,l-dimethylheptyl)- 6,6a,7,8,10,10a-hexahydro-l-hydroxy-6-6-dimethyl-9H-dibenzo[b,d]pyran-9-one and has the empirical formula C24H36O3. It has a molecular weight of 372.55. The structural formula is as follows:
Each 1 mg Cesamet capsule contains 1 mg of nabilone and the following inactive ingredients: povidone and corn starch. The capsule shells contain the following inactive ingredients: FD&C Blue No. 2 (indigo carmine), red iron oxide, gelatin, and titanium dioxide.
What are the possible side effects of nabilone (Cesamet)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using nabilone and call your doctor at once if you have any of these serious side effects:
- hallucinations (seeing or hearing things that are not there);
- paranoia, extreme fear;
- fast heart rate;
- feeling light-headed, fainting; or
- unusual thoughts or behavior.
Continue using nabilone and talk with your doctor if you have any of these less serious side...
What are the precautions when taking nabilone capsules (Cesamet)?
Before taking nabilone, tell your doctor or pharmacist if you are allergic to it; or to marijuana or related products; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high blood pressure, heart disease, mental/mood conditions (e.g., mania, depression, schizophrenia), personal or family history of regular use/abuse of drugs/alcohol/other substances.
This drug may make you dizzy or drowsy or affect your judgment. Do not drive, use machinery, or do any activity that requires alertness and clear thinking until you know how this...
Last reviewed on RxList: 1/14/2016
This monograph has been modified to include the generic and brand name in many instances.
Additional Cesamet Information
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