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Echinacea

Indications & Dosage
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INDICATIONS

Preparation, dosage and appropriate method of intake are still in debate however there are some general guidelines.

 One article reads "No well-controlled studies have evaluated the appropriate formulation or the dosages that are available on the market. Herbal publications typically state that the maximum adult daily dosage is 6 to 9 ml of expressed, fresh juice, 1.5 to 7.5 ml of tincture (preferred because not all the constituents are water soluble) or 2 to 5 g of dried root." 32

 "Daily intake should be restricted to what is deemed necessary. However, for the maintenance of a healthy immune system, echinacea is most wisely used periodically--a few weeks on, and a few weeks off, throughout the year." 60

 

TABLE 1 - Echinacea spp.; Compositae - Usual Dosage for Solid (Dry powdered) extract
Adults: 6.5:1 or 3.5% echinacoside at 150 to 300mg 3x/day
Children: No Studies conducted to date – Use with Extreme Care - Should not be given to children younger than 2 years old. Minimal dosages should be given to children 2yrs and older.

 

TABLE 2 - Echinacea spp.; Compositae - Usual Dosage for Solid (Freeze dried plant)
Adults: 325mg to 650mg/day
Children: No Studies conducted to date – Use with Extreme Care - Should not be given to children younger than 2 years old. Minimal dosages should be given to children 2yrs and older.

 

TABLE 3 – Echinacea Pallida Herba and Radix - Usual Dosage for Tincture 1: 5 ratio
Adults: 1:5 ratio using 50% (V/V) ethanol and native dried extract (50% ethanol in a 7 to 11:1 proportion) @ 900mg/ day.
Children: No Studies conducted to date – Use with Extreme Care - Should not be given to children younger than 2 years old. Minimal dosages should be given to children 2yrs and older.
TABLE 4 – Echinacea Purpurea Herba - Usual Dosage for Pressed Juice
Adults: Pressed Juice in concentration of 2.5:1, stabilized in 22% alcohol. – 6 to 9ml daily (internally)

External preparation should contain at least 15% expressed juice and be applied on a daily basis.

Children: No Studies conducted to date – Use with Extreme Care - Should not be given to children younger than 2 years old. Minimal dosages should be given to children 2yrs and older.
TABLE 5 - Echinacea Purpurea Radix - Usual Dosage for Tincture
Adults: Comminuted drug for decoctions and galvanized preparations – 30 to 60 drops 3X/day
Children: No Studies conducted to date – Use with Extreme Care - Should not be given to children younger than 2 years old. Minimal dosages should be given to children 2yrs and older.

Note: Preparations should be protected from light sources.

TABLE 6 - Echinacea Angustifolia Herba and Radix - Usual Dosage for Tea
Adults: Seep ½ teaspoon root in boiling water for 15 minutes. Drink 2-3x/day
Children: No Studies conducted to date – Use with Extreme Care - Should not be given to children younger than 2 years old. Minimal dosages should be given to children 2yrs and older.

Note: Preparations should be protected from light sources.

HOW SUPPLIED

It is usually orally taken in a solid or liquid form.

 

REFERENCES

  1. Kindscher, K Medicinal Wild Plants of the Prairie Lawrence: University Press of Kansas, 1992.
  2. John Lloyd: "History of Echinacea angustifolia", 1904
  3. Lloyd Brother''s "A Treatise on Echinacea", 1917
  4. Mark Blumenthal et. al.,: The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines, American Botanical Council, 1998, ISBN 096555550X
  5. US Pharmacopeia Press Release: USP Publishes Nine New Botanical Monographs. The Standard of Quality in Promoting the Public Health, November 2, 1998
  6. US Pharmacopeia Press Release: AMA Recognizes USP Role in Establishing Quality of Herbal Product, December 16, 1998
  7. Murray, M: Echinacea: Pharmacology and Clinical Applications, The American Journal of Natural Medicine. 2(l):18-24 (1995).
  8. Archives of Canedy D. Real Medicine or Medicine Show? Growth of Herbal Sales Raises Issues About Value. New York Times. July 23, 1998:C1.
  9. Edited by Timothy R. Tomlinson and Olayiwola Akerele: Medicinal Plants, Their Role in Health and Biodiversity, Robert S. McCaleb :The Medicinal Plant Marketplace, Akhtar Husain: Exploitation of Medicinal Plants, University of Pennsylvania Press, 1998, ISBN 0-8122-3431-6
  10. Francis Brinker, N.D.: Herb Contraindication and Drug Interactions, Eclectic Institute.1997 ISBN 0965913503
  11. Bauer R, Foster S: Analysis of Alkamides and Caffeic Acid Derivatives From Echinacea Simulata and E. paradoxa Roots, Planta Med , 1991 Oct, 57(5):447-9ISSN: 0032-0943
  12. Duke, James A. : Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants, Boca Raton, FL. CRC Press, 1992. ISBN 0849371929
  13. Steven Foster: Echinacea: Natures Immune Enhancer, Healing Arts Press, 1991
  14. Bauer R: Echinacea Drugs--Effects and Active Ingredients, (Echinacea-Drogen--Wirkungen und Wirksubstanzen: Z Arztl Fortbild), Jena, 1996 Apr, 90(2):111-5ISSN: 0044-2178 (Published in German)
  15. Parnham MJ: Benefit-Risk Assessment of the Squeezed Sap of the Purple Coneflower (Echinacea purpurea) for Long-term Oral Immunostimulation, Phytomed, 1996; 3:95-102
  16. Luettig B, Steinmuller C, Gifford G, Wagner-Matthes M: Macrophage Activation by the Polysaccharide Arabinogalactan Isolated from Plant Cell Cultures of Echinacea Purpurea, J Natl Cancer Inst. 1989, May 3rd, 81(9)669-675.
  17. Roesler J, Steinmuller C, Kiderlen A, Emmendorffer A, Wagner H, Lohmann-Matthes M. Application of Purified Polysaccharides from Cell Cultures of the Plant Echinacea Purpurea to Test Subjects Mediates Activation of the Phagocyte System. Int J Immunopharmacol, 1991, 13: 931-941
  18. Luettig B, Steinmuller C, Gifford G, Wagner-Matthes M: Macrophage Activation by the Polysaccharide Arabinogalactan Isolated from Plant Cell Cultures of Echinacea Purpurea, J Natl Cancer Inst. 1989, 81:669-675
  19. Bauer VR, Jurcic K, Puhlmann J, Wagner H: Immunologic: In Vivo and In Vitro Studies on Echinacea Extracts (Immunologische In-vivo- und In-vitro-Untersuchungen mit Echinacea- Extrakten), Arzneimittelforschung, 1988 Feb, 38(2):276-81ISSN: 0004-4172 (Published in German)
  20. Lersch C, Seuner M, Bauer A, Siemens M, Hart R, Drescher M. Nonspecific Immunostimulation with Low Doses of Cyclophosphamide (LDCY), Thymostimulin, and Echinacea Purpurea Extracts (Echinacin) in Patients with Far-Advanced Colorectal Cancers: Preliminary Results., Cancer Invest. 1992, ;10:343-348.
  21. Wildfeuer A, Mayerhofer D: The Effects of Plant Preparations on Cellular Functions in Body Defense (Untersuchung des Einflusses von Phytopraparaten auf zellulare Funktionen der korpereigenen Abwehr), Arzneimittelforschung),1994, Mar, 44(3):361-6ISSN: 0004-4172 (Published in German)Muller-Jacki B, Breu WPA, Redl K, Greger H, Bauer R: In vitro Inhibition of Cyclooxygenase and 5-lipoxygenase by Alkamides from Echinacea and Achillea species, Planta Medica. 1994, 60:37-40.
  22. Stahl M, Reifenberg K, Okpanyi S, Losch U: Porcine Granulocyte Functions: Evaluation and Modulation., Zentralbl Veterinarmed, 1990 June, 37(4):261-7ISSN: 0931-1793
  23. Wagner and Proksch: Economic and Medicinal Plant Research, Academic Press, Orlando, 1985, p.113
  24. Broumand N, et al.: In Vitro Effects of Echinacea and Ginseng on Natural Killer and Antibody-Dependent Cell Cytotoxicity in Healthy Subjects and Chronic Fatigue Syndrome or Acquired Immunodeficiency Syndrome Patients., Immunopharmacology, 1997, 35(3):229-235.
  25. Bauer VR Jurcic K Puhlmann J Wagner H: [Immunologic in vivo and in vitro studies on Echinacea extracts, (Immunologische In-vivo- und In-vitro-Untersuchungen mit Echinacea- Extrakten.), Arzneimittelforschung, 1988, Feb, 38 (2):276-81, ISSN: 0004-4172 (Published in German)
  26. Facino RM, Carini M, Aldini G, Marinello C, Arlandini E, Franzoi L, Colombo M, Pietta P, Mauri P: Direct Characterization of Caffeoyl Esters with Antihyaluronidase Activity in Crude Extracts from Echinacea Angustifolia Roots by Fast Atom Bombardment Tandem mass Spectrometry, Farmaco, 1993, Oct, 48(10):1447-61
  27. Mengs U, Clare CB, Poiley JA: Toxicity of Echinacea Purpurea. Acute, Subacute and Genotoxicity Studies, Arzneimittelforschung, 1991, Oct, 41(10):1076-81ISSN: 0004-4172
  28. Bone, K: Echinacea: What Makes It Work?, Medi Herb, 1997, 30:19-23.
  29. Vestweber AM, Beuth J Ko, HL Tunggal L, Buss G, Pulverer G: In Vitro Activity of Mercurius Cyanatus Complex Against Relevant Pathogenic Bacterial Isolates, (In-vitro-Aktivitat von Mercurius cyanatus-Komplex gegenuber relevantenpathogenen Bakterienisolaten), Arzneimittelforschung, 1995, Sep, 45(9):1018-20ISSN: 0004-4172 (Published in German)
  30. Roesler J, Steinmuller C, Kiderlen A, Emmendorffer A, Wagner H, Lohmann-MatthesML: Application of Purified polysaccharides from Cell Cultures of the Plant Echinacea Purpurea to Mice Mediates Protection Against Systemic Infections with Listeria monocytogenes and Candida albicans., Int J Immunopharmacol, 1991, 13(1):27-37ISSN: 0192-0561
  31. C Roesler, J Grottrup, E Franke, G Wagner, H Lohmann-Matthes ML: Polysaccharides Isolated from Plant Cell Cultures of Echinacea Purpurea Enhance the Resistance of Immuno-suppressed Mice Against Systemic Infections with Candida albicans and Listeria monocytogenes, Int J Immunopharmacol, 1993, Jul, 15(5):605-14ISSN: 0192-0561
  32. Zink, Therese M.D., M.P.H., Chaffin, Jodi, R.PH: Herbal ''Health'' Products: What Family Physicians Need to Know, American Family Physician, October 1, 1998
  33. Melchart D, Linde K, Worku F, Bauer R, Wagner H. Immunomodulation with Echinacea: A Systematic Review of Controlled Clinical Trials., Phytomedicine, 1994, 1:245-254.
  34. Tragni E, Galli CL, Tubaro A, Del Negro P, Della Loggia R: Anti-inflammatory Activity of Echinacea Angustifolia Fractions Separated on the Basis of Molecular Weight., Pharmacol Res Commun, 1988, Dec;20 Suppl 5:87-90, ISSN: 0031-6989
  35. Tragni E, Galli CL, Tubaro A, Del Negro P, Della Loggia R: Anti-inflammatory Activity of Echinacea Angustifolia Fractions Separated on the Basis of Molecular Weight., Pharmacol Res Commun, 1988, Dec;20 Suppl 5:87-90
  36. Hobbs, Christofer: Echinacea: From Native American Panacea to Modern Phytopharmaceutical, 1996
  37. Elsasser-Beile U, Willenbacher W, Bartsch HH, Gallati H, Schulte Monting J, vonKleist S: Cytokine production in Leukocyte Cultures During Therapy with Echinacea extract., J Clin Lab Anal, 1996, 10(6):441-5 ISSN: 0887-8013
  38. Stimpel M, Proksch A, Wagner H, Lohmann-Matthes ML: Macrophage Activation and Induction of Macrophage Cytotoxicity by Purified Polysaccharide Fractions from the Plant Echinacea Purpurea., Infect Immun, 1984 Dec, 46(3):845-9
  39. Jurcic, et al.: Zeitschrift fur Phytotherapie, 1989, 10 (2).
  40. Schumacher A, Friedberg KD: The Effect of Echinacea Angustifolia on Non-specific Cellular Immunity in the Mouse (Untersuchungen zur Wirkung von Echinacea angustifolia auf die unspezifischezellulare Immunantwort der Maus), Arzneimittelforschung, 1991, Feb, 41(2):141-7ISSN: 0004-4172 (Published in German)
  41. Gaisbauer M, Schleich T, Stickl HA, Wilczek I: The Effect of Echinacea Purpurea Moench on Phagocytosis in Granulocytes Measured by Chemiluminescence (Untersuchungen zum Einfluss von Echinacea purpurea Moench auf die Phagozytosevon Granulozyten mittels Messung der Chemilumineszenz.), Arzneimittelforschung, 1990, May, 40(5):594-8ISSN: 0004-4172 (Published in German)
  42. DM Broumand N, Sahl L, Tilles JG: In Vitro Effects of Echinacea and Ginseng on Natural Killer and Antibody-dependent Cell Cytotoxicity in Healthy Subjects and Chronic Fatigue syndrome or Acquired Immunodeficiency Syndrome Patients., Immunopharmacology, 1997, Jan, 35(3):229-35ISSN: 0162-3109
  43. Braunig B, Dorn M, Limburg E, Knick E: Enhancement of Resistance in Common Cold by Echinacea Purpurea., Z Phytother, 1992;13:7-13.
  44. Schoneberger D: Influence of the Immunostimulating Effects of the Pressed Juice of Echinaceae Purpureae on the Duration and Intensity of the Common Cold: Results of a Double-blind Clinical Trial. Forum Immunol. 1992;2:18-22.
  45. Melchart D, Walther E, Linde K, Brandmaier R, Lersch C: Echinacea Root Extracts for the Prevention of Upper Respiratory Tract Infections: A Double-blind, Placebo-controlled Randomized Trial., . Arch Fam Med, 1998, Nov-Dec;7(6):541-5
  46. Dorn M, Knick E, Lewith G. Placebo-controlled, Double-blind Study of Echinacea Pallida Radix in Upper Respiratory Tract Infections., J Allergy Clin Immunol, 1995, 95:1133-8.
  47. Galea S, Thacker K: Comp Ther Med,, 1997; 5:40-42.
  48. Hoheisel O, Sandberg M, Bertram S, et al.: Echinagard Treatment Shortens the Course of the Common Cold: a Double-blind, Placebo-controlled Clinical Trial., Eur J Clin Res, 1997, 9:261-8.
  49. Burger RA, Torres AR, Warren RP, Caldwell VD, Hughes BG: Echinacea-induced Cytokine Production by Human Macrophages., Int J Immunopharmacol, 1997, Jul;19(7):371-9
  50. Melchart D, Linde K, Worku F, Sarkady L, Holzmann M, Jurcic K, Wagner H: Results of Five Randomized Studies on the Immunomodulatory Activity of Preparations of Echinacea., J Altern Complement Med,1995, Summer;1(2):145-60
  51. Tragni E, Galli CL Tubaro A Del Negro P Della Loggia R Anti-inflammatory activity of Echinacea angustifolia fractions separated on the basis of molecular weight., Pharmacol Res Commun (1988 Dec) 20 Suppl 5:87-90ISSN: 0031-6989
  52. Wacker, Hilbig: Planta Medic, 1978, 33(1): 89-102.
  53. Facino RM, Carini M, Aldini G, Saibene L, Pietta P, Mauri P: Echinacoside and Caffeoyl Conjugates Protect Collagen from Free Radical-Induced Degradation: A Potential Use of Echinacea Extracts in the Prevention of Skin Photo damage, Planta Med, 1995, Dec, 61(6):510-4ISSN: 0032-0943
  54. Paranich AV, Pocherniaeva V, Dubinskaia GM, Mishchenko VP, Mironova NG, GugaloVP, Nazarets VV: Effect of Supposed Radioprotectors on Oxidation-Reduction of Vitamin E in the Tissues of Irradiated Rats, (Izuchenie vliianiia predpolagaemykh radioprotektorov na sostoianie redoks-sistemy vitamina E v tkaniakh obluchennykh krys), Radiats Biol Radioecol, 1993, Sep-Oct, 33(5):653-7ISSN: 0869-8192 (Published in Russian).
  55. Thompson KD: Antiviral Activity of Viracea Against cyclovir Susceptible and cyclovir Resistant Strains of Herpes Simplex Virus., Antiviral Res, 1998, Jul, 39(1):55-61
  56. Onkologie, 1987, Jun, 10(3 Suppl) 27-33
  57. Mullins RJ : Med J Aust, 1998, Feb 16;168(4):170-1
  58. Miller LG: Arch Intern Med Herbal Medicinals: Selected Clinical Considerations Focusing on Known or Potential Drug-herb Interactions., 1998 Nov 9;158(20):2200-11
  59. Mengs U, Clare C, Poiley J. : Toxicity of Echinacea purpurea: acute, subacute and genotoxicity studies. Arzneim Forsch., 1991, 41:1076-1081.
  60. Dr. Daniel Mowrey: Review of Echinacea, Next Generation Herbal Medicine

 

Additional References:

 

  • Snow, J.: Echinacea (Moench) Spp. Asteracae, The Protocol Journal of Botanical Medicine. 20:18-23 (1997).
  • HerbalGram. Echinacea: A Literature Review. Austin, Tex.: Herbal News, 1994;30(Suppl):33-48.
  • Wagner H, Jurcic K: Immunologic Studies of Plant Combination Preparations. In-vitro and In-vivo studies on the Stimulation of Phagocytosis (Immunologische Untersuchungen von pflanzlichen Kombinationspraparaten. In-vitro-und In-vivo-Studien zur Stimulierung der Phagozytosefahigkeit), Arzneimittelforschung (1991 Oct) 41(10):1072-6ISSN: 0004-4172 (Published in German)
  • Schutte A: Is Research in Veterinary Homeopathy Justified? Thoughts Concerning Principles and Synopsis of 5 Years of Research on the Subject, "Use of Homeopathy in Domestic Animals, at the Branch of the Free University of Berlin in Schwarzenbek (Ist Forschung in der Veterinarhomoopathie gerechtfertigt? Grundsatzgedanken undeine Zusammenschau uber 5 Jahre Forschung zum Thema "Anwendung der Homoopathiebei Nutztieren" an der Aussenstelle der Freien Universitat Berlin in Schwarzenbek), Berl Munch Tierarztl Wochenschr (1994 Jul) 107(7):229-36ISSN: 0005-9366 (Published in German)
  • Bukovsky M, Kostalova D, Magnusova R, Vaverkova S: Testing for Immunomodulating Effects of Ethanol-water Extracts of the Above-ground Parts of the Plants Echinaceae (Moench) and Rudbeckia L. (Testovanie imunomodulacnych ucinkov etanolovo-vodnych extraktov z nadzemnychcasti rastlin rodu Echinacea Moench a Rudbeckia L.), Cesk Farm (1993 Oct) 42(5):228-31ISSN: 0009-0530 (Published in Slovak)
  • Bukovsky M, Vaverkova S, Kostalova D, Magnusova R, Immunomodulating Activity of Ethanol-Water Extracts of the Roots of Echinacea gloriosa L., Echinacea angustifolia DC. and Rudbeckia speciosa Wenderoth Tested on the Immune System in C57BL6 Inbred Mice, (Imunomodulacna aktivita etanolovo-vodnych extraktov z korennov Echinaceagloriosa L., Echinacea angustifolia DC. a Rudbeckia speciosa Wenderoth testovanana imunitnom systeme inbrednych mysi C57BL6), Cesk Farm, 1993, Aug, 42(4):184-7 ISSN: 0009-0530 (Published in Slovak)
  • Domio M: Sparking the Decision of Choice between HIV Treatment Regimens: Western vs.Naturo- and Homeopathic Medicine, Int Conf AIDS, 1996, Ju,l 7-12, 11(2):424 (abstract no. Th.D.5121)
  • Egert D, Beuscher N: Studies on Antigen Specifity of Immunoreactive Arabinogalactan Proteins extracted from Baptisia tinctoria and Echinacea purpurea, Planta Med, 1992, Apr, 58(2):163-5ISSN: 0032-0943
  • Muller-Jakic B, Breu W, Probstle A, Redl K, Greger H, Bauer R: In vitro Inhibition of Cyclooxygenase and 5-Lipoxygenase by Alkamides from Echinacea and Achillea Species, Planta Med, 1994, Feb, 60(1):37-40ISSN: 0032-0943
  • Bukovsky M, Vaverkova S, Kost''alova D: Immunomodulating Activity of Echinacea Gloriosa L., Echinacea Angustifolia DC.and Rudbeckia Speciosa Wenderoth Ethanol-water Extracts: Pol J Pharmacol, 1995, Mar-Apr, 47(2):175-7ISSN: 1230-6002
  • Dorsch W: Clinical Application of Extracts of Echinacea Purpurea or Echinacea Pallida. Critical Evaluation of Controlled Clinical Studies (Klinische Anwendung von Extrakten aus Echinacea purpurea oder Echinacea pallida.Kritische Wertung kontrollierter klinischer Studien)., Z Arztl Fortbild (Jena), 1996, Apr, 90(2):117-22ISSN: 0044-2178 (Published in German)
  • Schranner I, Wurdinger M, Klumpp N, Losch U, Okpanyi SN: Modification of Avian Humoral Immunoreactions by Influex and Echinacea Angustifolia Extract, (Beeinflussung der aviaren humoralen Immunreaktionen durch Influex und Echinacea Angustifolia Extrakt)., Zentralbl Veterinarmed [B], 1989, Jul, 36(5):353-64ISSN: 0931-1793 (Published in German)
  • Schulthess BH, Giger E, Baumann TW: Echinacea: Anatomy, Phytochemical Pattern, and Germination of the Achene, Planta Med, 1991 Aug, 57(4):384-8ISSN: 0032-0943
  • Wichtl, M (ed), Herbal Drugs and Phytopharmaceuticals, CRC Press, 1994
  • Francis Brinker, N.D., Herb Contraindication and Drug Interactions, Eclectic Institute.1997 ISBN 0-9659135-0-3
  • Edited by Timothy R. Tomlinson and Olayiwola Akerele: Medicinal Plants, Their Role in Health and Biodiversity, Robert S. McCaleb :The Medicinal Plant Marketplace, Akhtar Husain: Exploitation of Medicinal Plants, University of Pennsylvania Press, 1998, ISBN 0-8122-3431-6
  • Reader Digest: The Family Guide to Natural Medicine, 1993, the Reader’s Digest Association, Inc., ISBN 0-89577-433-X.
  • R.C. Wren, F.L.S.: Potter’s New Cyclopedia of botanical drugs and preparations, Potter and Clark, 1907, ISBN 0 85032 009 7
  • Michael Castleman: The Healing Herbs , Bantam Books, 1991,ISBN 0-553-56988-0
  • Duke, James A.: Handbook of Biologically Active Phytochemicals and Their Activities, Boca Raton, FL., CRC Press, 1992
  • Michael A Weiner, Ph.D & Janet A. Weiner: Herbs that Heal, 1994, Quantum Books, ISBN 0-912845-11-
  • Time Life: The Drug and Natural Medicine Advisor,, 1997, Time-Life Books, ISBN 0-7835-4938-5/ 0-7835-5300-5
  • Michael Murray, N.D. and Joseph Pizzorno, N.D: Encyclopedia of Natural Medicine, 1998, Prima Publishing, ISBN 0-7615-1157-1
  • Michael Tierra, C.A., N.D.: The way of Herbs, Pocket Books, 1990, ISBN, 0-671-72403-7
  • Steven Foster: Echinacea: Natures Immune Enhancer, Healing Arts Press, 1991
  • Kindscher, K Medicinal Wild Plants of the Prairie Lawrence: University Press of Kansas, 1992. p. 86.
  • Snow, J. "Echinacea (Moench) Spp. Asteracae." The Protocol Journal of Botanical Medicine. 20:18-23 (1997).
  • Murray, M. "Echinacea: Pharmacology and Clinical Applications." The American Journal of Natural Medicine. 2(l):18-24 (1995).
  • Schulthess BH, Giger E, Baumann TW: Echinacea: Anatomy, Phytochemical Pattern, and Germination of the Achene., Planta Med, 1991, Aug, 57(4):384-8ISSN: 0032-0943
  • Paranich AV, Pocherniaeva VF, Dubinskaia GM, Mishchenko VP, Mironova NG, GugaloVP, Nazarets VV : Effect of Supposed Radio Protectors on Oxidation-Reduction of Vitamin E in the Tissues of Irradiated Rats, (Izuchenie vliianiia predpolagaemykh radioprotektorov na sostoianie redoks-sistemy vitamina E v tkaniakh obluchennykh krys)., Radiats Biol Radioecol, , Sep-Oct, 33(5):653-7ISSN: 0869-8192
  • C Hobbs: Echinacea Pharmacy in History, C. Hobbs 11/7/91 7
  • Voaden D, Jacobson M: Tumor Inhibitors. 3. Identification and Synthesis of an Oncolytic Hydrocar Bon from American Coneflower Roots., J Med Chem 15:619-23, 1972
  • Wacker A, Hilbig W: Virus-Inhibition by Echinacea Purpurea, Planta Med 1978 Feb;33(1):89-102 (Published in German)
  • Wagner V, Proksch A, Riess-Maurer, et al: Immunostimulating Polysaccharides (Heteroglycanes) of Higher Plants - Preliminary Communication, Arzneim Forsch 34:659-660, 1984
  • Mose J: Effect of Echinacin on Phagocytosis and Natural Killer Cells., Med Welt 34: 1463-7, 1983
  • Donald J. Brown, N.D: Phytotherapy Review and Commentary: Med J Aust ,1998. Feb 16;168(4):170-1 - Letter for Doctors and Patients, Townsend Letters 1998

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DOSAGE AND ADMINISTRATION

HOW SUPPLIED

Brand Name: Echinacea
Generic Name: Echinacea
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