If patient has been given ipecac syrup, DO NOT give ACTIDOSE WITH SORBITOL or ACTIDOSE-AQUA until after last vomiting episode. Do not use in persons who are not fully conscious. Do not use this product unless directed by a health professional, if turpentine, corrosives, such as alkalies (lye) and strong acids, or petroleum distillates, such as kerosene, gasoline, paint thinner, cleaning fluid or furniture polish, have been ingested. This product is not recommended for use in children weighing less than 32 kg, or during multiple dose activated charcoal therapy since excessive catharsis and significant fluid and electrolyte abnormalities may occur.

Keep this and all drugs out of the reach of children.

Do not use Actidose with Sorbitol or Actidose-Aqua in any person known to have a rare autosomal recessive genetic intolerance to fructose. Do not use Actidose with Sorbitol in patients who are dehydrated. Actidose with Sorbitol may cause excessive diarrhea.

Actidose with Sorbitol and Actidose-Aqua should be used in a supervised medical facility or under the direction of a physician or poison control center.

Actidose with Sorbitol and Actidose-Aqua are adjuncts in the management of poisoning emergencies. Prior to the use of activated charcoal, proper basic life support measures must be implemented as well as the appropriate gastric emptying technique if indicated.

When Actidose with Sorbitol or Actidose-Aqua are used to treat a poisoning emergency, the patient and healthcare providers should be aware that activated charcoal will produce black stools. These stools may be diarrhetic and may persist for several hours.

Actidose with Sorbitol may produce a profound cathartic effect and proper attention should be given to the patient's fluid and electrolyte needs. Actidose with Sorbitol should be used cautiously in patients receiving multiple dose activated charcoal. If Actidose with Sorbitol is used at each dosage interval, profound catharsis may develop which could result in dehydration, hypotension and significant electrolyte and fluid abnormalities.

A study conducted in healthy adult human volunteers who ingested therapeutic amounts of activated charcoal and sorbitol resulted in severe prolonged diarrhea, but no significant changes were noted in serum electrolytes or osmolality, BUN, or the metabolic profile as compared to the control.⁸

Gastrointestinal obstruction from activated charcoal may occur as a consequence of toxin-induced antiperistaltic effects. Actidose with Sorbitol and Actidose-Aqua should be used cautiously in patients who have been exposed to toxins which interfere with gastrointestinal tract peristalsis (i.e., anticholinergics, opioids, etc.). Bowel sounds should be frequently monitored to assess peristaltic action, especially in patients under going multiple dose activated charcoal therapy.

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