Alphagan-P
ALPHAGAN® P
(brimonidine tartrate) Ophthalmic Solution) 0.1% and 0.15%
DRUG DESCRIPTION
ALPHAGAN P (brimonidine tartrate ophthalmic solution) is a relatively selective alpha-2 adrenergic agonist for ophthalmic use. The chemical name of brimonidine tartrate is 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate. It is an off-white to pale yellow powder. It has a molecular weight of 442.24 as the tartrate salt, and is both soluble in water (0.6 mg/mL) and in the product vehicle (1.4 mg/mL) at pH 7.7. The structural formula is:
Formula: C11H10BrN5•C4H6O6
CAS Number: 70359-46-5
In solution, ALPHAGAN® P (brimonidine tartrate ophthalmic solution) has a clear, greenish-yellow color. It has an osmolality of 250-350 mOsmol/kg and a pH of 7.4-8.0 (0.1%) or 6.6-7.4 (0.15%).
Each mL of ALPHAGAN®P contains:
Active ingredient: brimonidine tartrate 0.1% (1.0 mg/mL) or 0.15% (1.5 mg/mL)
Inactives: sodium carboxymethylcellulose; sodium borate; boric acid; sodium chloride; potassium chloride; calcium chloride; magnesium chloride; Purite® 0.005% (0.05mg/mL) as a preservative; purified water; with hydrochloric acid and/or sodium hydroxide to adjust pH.
Generic Name: Brimonidine Tartrate
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