Altace
Altace® Tablets
(ramipril) Tablets
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus.When pregnancy is detected, Ramipril should be discontinued as soon as possible. See WARNINGS: Fetal/neonatal morbidity and mortality.
DRUG DESCRIPTION
Altace (ramipril)
Altace drug belongs to a group of medications called ACE inhibitors. It is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks and kidney problems.
Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar organic solvents and buffered aqueous solutions. Ramipril melts between 105°C and 112°C.
The CAS Registry Number is 87333-19-5. Ramipril's chemical name is (2S,3aS,6aS)-1[(S)-N-[(S)-1-Carboxy-3-phenylpropyl] alanyl] octa hydrocyclopenta [b]pyrrole-2-carboxylic acid, 1-ethyl ester; its structural formula is:
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Its empiric formula is C23H32N2O5, and its molecular weight is 416.5.
Ramiprilat, the diacid metabolite of ramipril, is a non-sulfhydryl angiotensin converting enzyme inhibitor. Ramipril is converted to ramiprilat by hepatic cleavage of the ester group.
ALTACE Tablets (ramipril) are supplied as tablets for oral administration containing 1.25 mg, 2.5 mg, 5 mg and 10 mg of ramipril. The inactive ingredients present are calcium sulphate dihydrate, pregelatinized starch, sodium bicarbonate, and sodium stearyl fumarate. The 2.5 mg tablet contains yellow iron oxide and FD&C yellow #6, the 5 mg tablet contains FD&C yellow #6 and FD&C red #40, and the 10 mg tablet contains FD&C blue #2.
Generic Name: Ramipril Tablets
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