Amoxapine tablets are indicated for the relief of symptoms of depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions. It is indicated for depression accompanied by anxiety or agitation.

Effective dosage of Amoxapine Tablets may vary from one patient to another. Usual effective dosage is 200 to 300 mg daily. Three weeks constitutes adequate period of trial, providing dosage has reached 300 mg daily (or lower level of tolerance ) for at least two weeks. If no response is seen at 300 mg dosage may be increased, depending upon tolerance, up to 400 mg daily. Hospitalized patients, who have been refractory to antidepressant therapy and who have no history of convulsive seizures, may have dosage raised cautiously up to 600 mg daily in divided doses.

Amoxapine tablets may be given in a single daily dose not to exceed 300 mg preferably at bedtime. If the total daily dose exceeds 300 mg, dosage should be given in divided doses.

Initial Dosage for Adults: Usual starting dosage is 50 mg two or three times daily. Depending upon tolerance, dosage may be increased to 100 mg two or three times daily by the end of the first week. Initial dosage of 300 mg daily may be given, but notable sedation may occur in some patients during the first few days of therapy at this level. Increases above 300 mg daily should be made only if 300 mg daily has been ineffective during a trial period of at least two weeks. When effective dosage is established the drug may be given in a single dose (not to exceed 300 mg) at bedtime.

Elderly Patients: In general lower dosages are recommended for these patients. Recommended starting dosage ot Amoxapine Tablets is 25 mg two or three times daily if no intolerance is observed, dosage may be increased by the end of the first week to 50 mg two or three times daily. Although 100-150 mg daily may be adequate for many elderly patients, some may require higher dosage. Careful increases up to 300 mg daily are indicated in such cases.

Once an effective dosage is established, Amoxapine Tablets may conveniently be given in a single bedtime dose, not to exceed 300 mg.

Maintenance: Recommended maintenance dosage of Amoxapine Tablets is the lowest dose that wilt maintain remission. If symptoms reappear, dosage should be increased to the earlier level until they are controlled. For maintenance therapy at dosages of 300 mg or less, a single dose at bedtime is recommended.

Amoxamine Tablets USP ale supplied as follows

25 mg white, round, bisected tablets, debossed with Watson 379.

100 mg blue. round, bisected tablets, debossed with Watson 381.

50 mg salmon, round. bisected tablets, debossed with Watson 380

Bottles of 30 and 100 tablets are supplied with a child resistant closure.

Store at controlled room temperature, 15°-30° C (59°-86° F).

Dispense in a light container as defined in the USP.

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