Kineret^® (anakinra) is a recombinant, nonglycosylated form of the human interleukin-1 receptor antagonist (IL- IRa). Kineret^® differs from native human IL-IRa in that it has the addition of a single methionine residue at its amino terminus. Kineret^® consists of 153 amino acids and has a molecular weight of 17.3 kilodaltons. It is produced by recombinant DNA technology using an E coli bacterial expression system.

Kineret^® is supplied in single use prefilled glass syringes with 27 gauge needles as a sterile, clear, colorless-to-white, preservative-free solution for daily subcutaneous (SC) administration. Each prefilled glass syringe contains: 0.67 mL (100 mg) of anakinra in a solution (pH 6.5) containing sodium citrate (1.29 mg), sodium chloride (5.48 mg), disodium EDTA (0.12 mg), and polysorbate 80 (0.70 mg) in Water for Injection, USP.

Bookmark this page: