The expected manifestations of Aranesp® overdosage include signs and symptoms associated with an excessive and/or rapid increase in hemoglobin concentration, including any of the cardiovascular events described in WARNINGS and listed in ADVERSE REACTIONS. Patients receiving an overdosage of Aranesp® should be monitored closely for cardiovascular events and hematologic abnormalities. Polycythemia should be managed acutely with phlebotomy, as clinically indicated. Following resolution of the effects due to Aranesp® overdosage, reintroduction of Aranesp® therapy should be accompanied by close monitoring for evidence of rapid increases in hemoglobin concentration ( > 1 g/dL in any 2-week period). In patients with an excessive hematopoietic response, reduce the Aranesp® dose in accordance with the recommendations described in DOSAGE AND ADMINISTRATION.

Aranesp® is contraindicated in patients with:

• uncontrolled hypertension
• known hypersensitivity to the active substance or any of the excipients

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