TENORETIC® (atenolol and chlorthalidone) is for the treatment of hypertension. It combines the antihypertensive activity of two agents: a beta1-selective (cardioselective) hydrophilic blocking agent (atenolol, TENORMIN®) and a monosulfonamyl diuretic (chlorthalidone). Atenolol is Benzeneacetamide, 4-[2'-hydroxy-3'-[(1-methylethyl) amino] propoxy]-.

Atenolol (free base) is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/mL at 37° C. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less soluble in chloroform (3 mg/mL at 25°C).

Chlorthalidone is 2-Chloro-5-(1-hydroxy-3-oxo-1- isoindolinyl) benzene sulfonamide:

Chlorthalidone has a water solubility of 12 mg/100 mL at 20°C.

Each TENORETIC 100 Tablet contains:

Atenolol (TENORMIN®) ....................................... 100 mg
Chlorthalidone ........................................................ 25 mg

Each TENORETIC 50 Tablet contains:

Atenolol (TENORMIN®) ......................................... 50 mg
Chlorthalidone .......................................................... 25 mg

Inactive ingredients: magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.

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