The ATRIDOX® product* is a subgingival controlled-release product composed of a 2 syringe mixing system. Syringe A contains 450 mg of the ATRIGEL® Delivery System, which is a bioabsorbable, flowable polymeric formulation composed of 36.7% poly (DL-lactide) (PLA) dissolved in 63.3% N- ethyl-2-pyrrolidone (NMP). Syringe B contains doxycycline hyclate which is equivalent to 42.5 mg doxycycline. The constituted product is a pale yellow to yellow viscous liquid with a concentration of 10% of doxycycline hyclate. Upon contact with the crevicular fluid, the liquid product solidifies and then allows for controlled release of drug for a period of 7 days.

Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. The structural formula of doxycycline hyclate is:

Empirical Formula: (C₂₂H₂₄N₂O₈•HCI)₂•C₂H₆O•H₂O

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