Patients being started on IMURAN should be informed of the necessity of periodic blood counts while they are receiving the drug and should be encouraged to report any unusual bleeding or bruising to their physician. They should be informed of the danger of infection while receiving IMURAN and asked to report signs and symptoms of infection to their physician. Careful dosage instructions should be given to the patient, especially when IMURAN is being administered in the presence of impaired renal function or concomitantly with allopurinol (see DRUG INTERACTIONS subsection and DOSAGE AND ADMINISTRATION). Patients should be advised of the potential risks of the use of IMURAN during pregnancy and during the nursing period. The increased risk of neoplasia following therapy with IMURAN should be explained to the patient.

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