In vitro serial dilution tests have shown that the spectrum of antibacterial activity of Bactrim includes common bacterial pathogens with the exception of Pseudomonas aeruginosa. The following organisms are usually susceptible: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis, indole-positive Proteus species including Proteus vulgaris, Haemophilus influenzae (including ampicillin-resistant strains), Streptococcus pneumoniae, Shigella flexneri and Shigella sonnei. It should be noted, however, that there are little clinical data on the use of Bactrim IV Infusion in serious systemic infections due to Haemophilus influenzae and Streptococcus pneumoniae.

REPRESENTATIVE MINIMUM INHIBITORY CONCENTRATION VALUES
FOR BACTRIM-SUSCEPTIBLE ORGANISMS (MIC µg/mL)

	TMP / SMX (1:20)
Bacteria	TMP alone	SMX alone	TMP	SMX
Escherichia coli	0.05-1.5	1.0-245	0.05-0.5	0.95-9.5
Proteus species   (indole positive)	0.5-5.0	7.35-300	0.05-1.5	0.95-28.5
Morganella morganii	0.5-5.0	7.35-300	0.05-1.5	0.95-28.5
Proteus mirabilis	0.5-1.5	7.35-30	0.05-0.15	0.95-2.85
Klebsiella species	0.15-5.0	2.45 -245	0.05-1.5	0.95-28.5
Enterobacter species	0.15-5.0	2.45-245	0.05-1.5	0.95-28.5
Haemophilus influenzae	0.15-1.5	2.85-95	0.015-0.15	0.285-2.85
Streptococcus pneumoniae	0.15-1.5	7.35-24.5	0.05-0.15	0.95-2.85
Shigella flexneri *	<0.01-0.04	<0.16->320	<0.002-0.03	0.04-0.625
Shigella sonnei *	0.02-0.08	0.625->320	0.004-0.06	0.08 -1.25
TMP = trimethoprim SMX = sulfamethoxazole * Rudoy RC, Nelson JD, Haltalin KC. Antimicrob Agents Chemother. May 1974;5:439-443.

Brand Name: Bactrim
Generic Name: Trimethoprim and Sulfamethoxazole

• « Previous
• Clinical Pharmacology
• Next »

Next: Bactrim - Patient Information »
« Previous: Bactrim - Overdosage & Contraindications

Bookmark this page: