Beclomethasone dipropionate is an anti-inflammatory corticosteroid having the chemical name 9-chloro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione17,21-dipropionate. Beclomethasone 17,21-dipropionate is a diester of beclomethasone, a synthetic corticosteroid which is chemically related to dexamethasone. Additional Information for Vanceril 84 mcg Oral Inhalation: Beclomethasone differs from dexamethasone only in having a chlorine at the 9a carbon in place of fluorine and in having a 16b-methyl group instead of a 16a-methyl group. Beclomethasone the following chemical structure:

Beclomethasone dipropionate is a white to creamy-white, odorless powder with a molecular formula of C₂₈H₃₇ClO₇ and a molecular weight of 521.05. It is very slightly soluble in water, very soluble in chloroform, and freely soluble in acetone and in alcohol.

Beclomethasone dipropionate oral and nasal inhalers are pressurized metered-dose aerosol units containing a microcrystalline suspension of beclomethasone dipropionate-trichloromonofluoromethane clathrate in a mixture of propellants (trichloromonofluoromethane and dichlorodifluoromethane) with oleic acid. Each canister contains beclomethasone dipropionate-trichloromonofluoromethane clathrate having a molecular proportion of beclomethasone dipropionate to trichloromonofluoromethane between 3:1 and 3:2.

Beclovent 42 mc Inhalation Aerosol: Each actuation delivers a quantity of clathrate equivalent to 42 mcg of beclomethasone dipropionate from the mouthpiece and 50 mcg from the valve. The contents of one 6.7-g canister provide at least 80 oral inhalations, and the contents of one 16.8-g canister provide at least 200 oral inhalations.

Vanceril 84 mcg Inhalation Aerosol: Each actuation delivers a quantity of clathrate equivalent to 84 mcg of beclomethasone dipropionate from the mouthpiece and 100 mcg of beclomethasone dipropionate from the valve. The contents of the 5.4 g and 12.2 g canisters provide at 40 and 120 oral inhalations, respectively.

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