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Celestone
CLINICAL PHARMACOLOGY
Celestone
Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs, such as betamethasone, are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.
Glucocorticoids, such as betamethasone, cause profound and varied metabolic effects. In addition, they modify the body's immune response to diverse stimuli.
Pharmacodynamics/Kinetics:
Protein Binding - 64%
Metabolism - Hepatic
T½ - 6.5 hrs
Excretion - Urine (<5% as unchanged drug)
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