No specific information is available on the treatment of overdosage with BONIVA. However, based on knowledge of this class of compounds, oral overdosage may result in hypocalcemia, hypophosphatemia, and upper gastrointestinal adverse events, such as upset stomach, dyspepsia, esophagitis, gastritis, or ulcer. Milk or antacids should be given to bind BONIVA. Due to the risk of esophageal irritation, vomiting should not be induced, and the patient should remain fully upright. Dialysis would not be beneficial.

• Known hypersensitivity to BONIVA or to any of its excipients
• Uncorrected hypocalcemia (see PRECAUTIONS: General)
• Inability to stand or sit upright for at least 60 minutes (see DOSAGE AND ADMINISTRATION)

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