The following adverse effects have been associated with the use of edetate calcium disodium:

Body as a Whole:   pain at intramuscular injection site, fever, chills, malaise, fatigue, myalgia, arthralgia.

Cardiovascular:   hypotension, cardiac rhythm irregularities.

Renal:   acute necrosis of proximal tubules (which may result in fatal nephrosis), infrequent changes in distal tubules and glomeruli.

Urinary:   glycosuria, proteinuria, microscopic hematuria and large epithelial cells in urinary sediment.

Nervous System:   tremors, headache, numbness, tingling.

Gastrointestinal:   cheilosis, nausea, vomiting, anorexia, excessive thirst.

Hepatic:   mild increases in SGOT and SGPT are common, and return to normal within 48 hours after cessation of therapy.

Immunogenic:   histamine-like reactions (sneezing, nasal congestion, lacrimation), rash.

Hematopoietic:   transient bone marrow depression, anemia,

Metabolic:   zinc deficiency, hypercalcemia.

There is no known drug interference with standard clinical laboratory tests. Steroids enhance the renal toxicity of edetate calcium disodium in animals. ⁷ Edetate calcium disodium interferes with the action of zinc insulin preparations by chelating the zinc. ⁷

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