MIC (mcg/mL)

Interpretation^c

<2

Susceptible (S)

When testing Streptococcus^d  

MIC (mcg/mL)

Interpretation

<0.5

Susceptible (S)

1

Intermediate (I)

>2

Resistant (R)

When testing Neisseria gonorrhoeae^e  

MIC (mcg/mL)

Interpretation^c

<0.5

Susceptible (S)

1. Staphylococci exhibiting resistance to methicillin/oxacillin, should be reported as also resistant to cefotaxime despite apparent in vitro susceptibility. 
2. Interpretive criteria is applicable only to tests performed by broth microdilution method using Haemophilus Test Media.²
3. The absence of resistant strains precludes defining any interpretations other than susceptible. 
4. Streptococcus pneumoniae must be tested using cation-adjusted Mueller-Hinton broth with 2-5% lysed horse blood.
5. Interpretive criteria applicable only to tests performed by agar dilution method using GC agar base with 1% defined growth supplement.² 

A report of †Susceptible† indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable. A report of †Intermediate† indicates that the result should be considered equivocal and if the microorganism is not fully susceptible to alternative clinically feasible drugs the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of †Resistant† indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable, other therapy should be selected. 

Standardized susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of the laboratory procedure. Standard cefotaxime sodium powder should provide the following MIC values:

	Microorganism	MIC (mcg/mL)
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