Susceptible (S)

26-27

Intermediate (I)

<25

Resistant (R)

When testing Neisseria gonorrhoeae^d

Zone Diameter (mm)

Interpretation^c

>31

Susceptible (S)

1. Staphylococci exhibiting resistance to methicillin/oxacillin, should be reported as also resistant to cefotaxime despite apparent in vitro susceptibility.
2. Interpretive criteria is applicable only to tests performed by disk diffusion method using Haemophilus Test Media.³
3. The absence of resistant strains precludes defining any interpretations other than susceptible.
4. Interpretive criteria applicable only to tests performed by disk diffusion method using GC agar base with 1% defined growth supplement.³

Interpretation should be as stated above for results using dilution techniques. Interpretation involves correlation of the diameter obtained in the disk test with the MIC for cefotaxime sodium.

As with standardized dilution techniques, diffusion methods require the use of laboratory control microorganisms that are used to control the technical aspects of the laboratory procedures. For the diffusion technique, the 30 mcg cefotaxime sodium disk should provide the following zone diameters in these laboratory test quality control strains:

1. Ranges applicable only to tests performed by disk diffusion method using Haemophilus Test Media.³
2. Ranges applicable only to tests performed by disk diffusion method using GC agar base with 1% defined growth supplement.³

Anaerobic Techniques:
For anaerobic bacteria, the susceptibility to cefotaxime sodium as MICs can be determined by standardized test methods.⁴ The MIC values obtained should be interpreted according to the following criteria:

	MIC (mcg/mL)	Interpretation
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