Overdosage of estrogen/progestin may cause nausea and vomiting, breast tenderness, abdominal pain, drowsiness/fatigue and withdrawal bleeding may occur in females. Treatment of overdose consists of discontinuation of PREMPRO or PREMPHASE together with institution of appropriate symptomatic care.

PREMPRO or PREMPHASE therapy should not be used in women with any of the following conditions:

1. Undiagnosed abnormal genital bleeding.
2. Known, suspected, or history of cancer of the breast.
3. Known or suspected estrogen-dependent neoplasia.
4. Active deep vein thrombosis, pulmonary embolism or a history of these conditions.
5. Active or recent (within past year) arterial thromboembolic disease (for example, stroke, myocardial infarction).
6. Liver dysfunction or disease.
7. Known hypersensitivity to any of the ingredients in PREMPRO or PREMPHASE
8. Known or suspected pregnancy.

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