ChiRhoStim
SIDE EFFECTS
Mild to moderate adverse reactions have been noted for synthetic human secretin in clinical studies in 533 patients and 51 healthy volunteers. Two severe adverse reactions, nausea and abdominal pain, occurred in one patient. Table 1 details the type and number of patients with adverse reactions.
TABLE 1 ADVERSE REACTIONS WITH CHIRHOSTIM®
| Adverse Reaction | N = 584 Incidence (Patients) |
| Nausea | 11(11) |
| Flushing | 4 (4) |
| Early removal of Dreiling tube | 3 (3) |
| Abdominal pain | 3 (3) |
| Vomiting | 3 (3) |
| Increased heart rate | 2 (2) |
| Mild Pancreatitis | 2 (2) |
| Upset stomach | 2 (2) |
| Anxiety | 1 (1) |
| Burning in stomach or abdomen | 1 (1) |
| Clammy skin | 1 (1) |
| Decreased O2 saturation | 1 (1) |
| Diarrhea | 1 (1) |
| Faintness | 1 (1) |
| Hypotension | 1 (1) |
| Infiltrated IV | 1 (1) |
| Oral secretions increased | 1 (1) |
| Sedation | 1 (1) |
| Slow heart rate (57 bpm) | 1 (1) |
| Tingling in legs | 1 (1) |
| Unresponsive | 1 (1) |
| Warm sensation in abdomen | 1 (1) |
| Warm sensation in face | 1 (1) |
Of the 584 patients and healthy volunteers treated with ChiRhoStim®, a total of 29 patients (5%) had at least one adverse reaction.
DRUG INTERACTIONS
The concomitant use of anticholinergic agents may make patients hyporesponsive to secretin stimulation and may produce a false result. Any results of secretin stimulation tests in these patients should thus be interpreted with caution.
Generic Name: Human Secretin
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ChiRhoStim
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