Chlor-Trimeton
SIDE EFFECTS
>10%:
Central nervous system: Slight to moderate drowsiness
Respiratory: Thickening of bronchial secretions
1% to 10%:
Central nervous system: Headache, excitability, fatigue, nervousness, dizziness
Gastrointestinal: Nausea, xerostomia, diarrhea, abdominal pain, appetite increase, weight gain
Genitourinary: Urinary retention
Neuromuscular & skeletal: Arthralgia, weakness
Ocular: Diplopia
Renal: Polyuria
Respiratory: Pharyngitis
DRUG INTERACTIONS
Substrate of CYP2D6 (minor), 3A4 (major); Inhibits CYP2D6 (weak).
Increased toxicity (CNS depression): CNS depressants, MAO inhibitors, tricyclic antidepressants, phenothiazines.
CYP3A4 inhibitors: May increase the levels/effects of chlorpheniramine. Example inhibitors include azole antifungals, ciprofloxacin, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone, nicardipine, propofol, protease inhibitors, quinidine, and verapamil.
Generic Name: Chlorpheniramine Maleate
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Chlor-Trimeton
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