THE MAJOR HAZARDS OF CODEINE, AS OF OTHER NARCOTIC ANALGESICS, ARE RESPIRATORY DEPRESSION AND, TO A LESSER DEGREE, CIRCULATORY DEPRESSION. RESPIRATORY ARREST, SHOCK, AND CARDIAC ARREST HAVE OCCURRED.

The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, nausea, vomiting, and sweating. These effects seem to be more prominent in ambulatory patients and in those who are not suffering severe pain. In such individuals, lower doses are advisable. Some adverse reactions may be alleviated in the ambulatory patient if he lies down.

Other adverse reactions include the following:

Central Nervous System — Euphoria, dysphoria, weakness, headache, insomnia, agitation, disorientation, and visual disturbances.

Gastrointestinal — Dr. mouth, anorexia, constipation, and biliary tract spasm.

Cardiovascular — Flushing of the face, bradycardia, palpitation, faintness, and syncope.

Genitourinary— Urinary retention or hesitancy, anti- diuretic effect, and reduced libido and/or potency.

Allergic— Pruritus, urticaria, other skin rashes, edema, and, rarely, hemorrhagic urticaria.