Corzide
CORZIDE® 40/5
CORZIDE® 80/5
Nadolol and Bendroflumethiazide Tablets
DRUG DESCRIPTION
CORZIDE (Nadolol and Bendroflumethiazide Tablets) for oral administration combines two antihypertensive agents: CORGARD® (nadolol), a nonselective beta-adrenergic blocking agent, and NATURETIN® (bendroflumethiazide), a thiazide diuretic-antihypertensive. Formulations: 40 mg and 80 mg nadolol per tablet combined with 5 mg ben-droflumethiazide. Inactive ingredients: cellulose, colorant (FD&C Blue No. 2), lactose, magnesium stearate, povi-done, sodium starch glycolate, and starch.
Nadolol
Nadolol is a white crystalline powder. It is freely soluble in ethanol, soluble in hydrochloric acid, slightly soluble in water and in chloroform, and very slightly soluble in sodium hydroxide.
Nadolol is designated chemically as 1-(tert-buty-lamino)-3-{(5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1-nap hthyl)oxy}-2-propanol. Structural formula:
Bendroflumethiazide
Bendroflumethiazide is a white crystalline powder. It is soluble in alcohol and in sodium hydroxide, and insoluble in hydrochloric acid, water, and chloroform.
Bendroflumethiazide is designated chemically as 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzoth iadiazine-7-sulfonamide 1,1-dioxide.
Generic Name: Nadolol and Bendroflumethiazide
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Corzide
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