Diprolene Lotion
DIPROLENEÒ
Brand of augmented betamethasone dipropionate lotion*
Lotion 0.05% (potency expressed as betamethasone)
* Vehicle augments the penetration of the steroid.
For Dermatologic Use Only
Not for Ophthalmic Use
DRUG DESCRIPTION
DIPROLENEÃ? (augmented betamethasone dipropionate lotion) Lotion contains betamethasone dipropionate, USP, a synthetic adrenocorticosteroid, for dermatologic use. Betamethasone, an analog of prednisolone, has a high degree of corticosteroid activity and a slight degree of mineralocorticoid activity. Betamethasone dipropionate is the 17, 21-dipropionate ester of betamethasone.
Chemically, betamethasone dipropionate is 9-fluoro-11b, 17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate, with the empirical formula C28H37FO7, a molecular weight of 504.6 and the following structural formula:
It is a white to creamy-white, odorless powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol.
Each gram of DIPROLENE Lotion 0.05% contains 0.643 mg betamethasone dipropionate, USP (equivalent to 0.5 mg betamethasone), in an augmented lotion base of purified water; isopropyl alcohol (30%); hydroxypropylcellulose; propylene glycol; sodium phosphate; phosphoric acid and sodium hydroxide used to adjust the pH.
Generic Name: Betamethasone Dipropionate
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Diprolene Lotion
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