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Periostat

Clinical Pharmacology
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Clinical Pharmacology

Periostat

93

93

78

Mean Gain in ALv   Periostat 20 mg BID

0.25 mm

1.03 mm*

1.55mm*

Placebo

0.20 mm

0.86 mm

1.17mm

Mean Decrease in PD   Periostat 20 mg BID

0.16 mm**

0.95mm**

1.68mm**

Placebo

0.05 mm

0.69 mm

1.20mm

% of Sites with loss of ALv >/= 2 mm   Periostat 20 mg BID

1.9 %

1.3 %

0.3%*

Placebo

2.2 %

2.4 %

3.6%

% of Sites with BOP   Periostat20 mg BID

39%**

64%*

75%

Placebo

46%

70%

80%


*p< 0.050 vs. the placebo control group, ** p< 0.010 vs. the placebo control group.

Brand Name: Periostat
Generic Name: Doxycycline Hyclate

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