INAPSINE (droperidol) is indicated:

• to produce tranquilization and to reduce the incidence of nausea and vomiting in surgical and diagnostic procedures.
• for premedication, induction, and as an adjunct in the maintenance of general and regional anesthesia.
• in neuroleptanalgesia in which INAPSINE is given concurrently with an opioid analgesic, such as SUBLIMAZE® (fentanyl citrate) Injection, to aid in producing tranquility and decreasing anxiety and pain.

Dosage should be individualized. Some of the factors to be considered in determining the dose are age, body weight, physical status, underlying pathological condition, use of other drugs, type of anesthesia to be used and the surgical procedure involved. Vital signs should be monitored routinely.

Usual Adult Dosage

I. Premedication - (to be appropriately modified in the elderly, debilitated and those who have received other depressant drugs) 2.5 to 10 mg (1 to 4 mL) may be administered intramuscularly 30 to 60 minutes preoperatively.

II. Adjunct to General Anesthesia - Induction - 2.5 mg (1 mL) per 20 to 25 pounds may be administered (usually intravenously) along with an analgesic and or general anesthetic. Smaller doses may be adequate. The total amount of INAPSINE (droperidol) administered should be titrated to obtain the desired effect based on the individual patient's response.

Maintenance - 1.25 to 2.5 mg (0.5 to 1 mL) usually intravenously.

III. Use without a general anesthetic in diagnostic procedures - Administer the usual I.M. premedication 2.5 to 10 mg (1 to 4 mL) 30 to 60 minutes before the procedure. Additional 1.25 to 2.5 mg (0.5 to 1 mL) amounts of INAPSINE may be administered, usually intravenously.

NOTE: When INAPSINE is used in certain procedures, such as bronchoscopy, appropriate topical anesthesia is still necessary.

IV. Adjunct to regional anesthesia - 2.5 to 5 mg (1 to 2 mL) may be administered intramuscularly or slowly intravenously when additional sedation is required.

Usual Children's Dosage

For children two to 12 years of age, a reduced dose as low as 1.0 to 1.5 mg (0.4 to 0.6 mL) per 20 to 25 pounds is recommended for premedication or for induction of anesthesia.

See WARNINGS, PRECAUTIONS, and DRUG INTERACTIONS for use of INAPSINE with other CNS depressants and in patients with altered response.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If such abnormalities are observed, the drug should not be administered.

INAPSINE (droperidol) Injection is available as:

PROTECT FROM LIGHT.

STORE AT ROOM TEMPERATURE 15° C-25° C (59° F-77° F).

Rx only

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