Acute overdosage with this combination elixir may produce variable clinical signs as hydrocodone produces CNS depression and cardiovascular depression while pseudoephedrine produces CNS stimulation and variable cardiovascular effects. Hydrocodone is likely to be responsible for most of the severe reactions from overdosage. Pressor amines should be used with great caution when taking pseudoephedrine. Patients with signs of stimulation should be treated conservatively and depressant medications should be avoided if possible because of potential drug interaction with hydrocodone.

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include drowsiness, nausea, vomiting, shaking, irregular heartbeat, slowed breathing, cold and clammy skin, and deep sleep or loss of consciousness.

This combination elixir is contraindicated in patients with severe hypertension, severe coronary artery disease, and in patients on MAO inhibitor therapy.

Hypersensitivity: Contraindicated in patients with hypersensitivity or idiosyncrasy to sympathomimetic amines, phenanthrene derivatives, or to any other formula ingredients.

Nursing Mothers: Contraindicated because of the higher than usual risk for infants for sympathomimetic amines.

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