Eloxatin (Oxaliplatin Injection) clinical pharmacology - prescription drugs and medications at RxList

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Eloxatin

Clinical Pharmacology

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Clinical Pharmacology

Eloxatin

The following tables show the baseline characteristics and dosing of the patient population entered into this study. The baseline characteristics were well balanced between arms.

Table 16 - Patient Characteristics in Adjuvant Therapy Study

	ELOXATIN + infusional 5-FU/LV N=1123	Infusional 5-FU/LV N=1123
Sex: Male (%)	56.1	52.4
Female (%)	43.9	47.6
Median age (years)	61.0	60.0
< 65 years of age (%)	64.4	66.2
≥ 65 years of age (%)	35.6	33.8
Karnofsky Performance Status (KPS) (%)
100	29.7	30.5
90	52.2	53.9
80	4.4	3.3
70	13.2	11.9
&le60	0.6	0.4
Primary site (%)
Colon including cecum	54.6	54.4
Sigmoid	31.9	33.8
Recto sigmoid	12.9	10.9
Other including rectum	0.6	0.9
Bowel obstruction (%)
Yes	17.9	19.3
Perforation (%)
Yes	6.9	6.9
Stage at Randomization (%)
II (T=3,4 N=0, m=0)	40.1	39.9
III (T=any, N=1,2, m=0)	59.6	59.3
IV (T=any, N=any, m=1)	0.4	0.8
Staging – T (%)
T1	0.5	0.7
T2	4.5	4.8
T3	76.0	75.9
T4	19.0	18.5
Staging – N (%)
N0	40.2	39.9
N1	39.4	39.4
N2	20.4	20.7
Staging – m(%)
M1	0.4	0.8

Table 17 - Dosing in Adjuvant Therapy Study

	ELOXATIN + infusional 5-FU/LV N=1108	Infusional 5-FU/LV N=1111
Median Relative Dose Intensity (%)
5-FU	84.4	97.7
ELOXATIN	80.5	N/A
Median Number of Cycles	12	12
Median Number of cycles with ELOXATIN	11	N/A