Continued injections of ephedrine (after depletion of norepinephrine from the nerve endings with loss of vasopressor effect) may result in hypotension more serious than that existing prior to the use of ephedrine. In the absence of norepinephrine depletion, excessive parenteral dosage produces tachycardia, exaggerated rise in blood pressure, and possible cerebrovascular bleeding, plus central nervous system effects. In the event of adverse blood pressure effects, the drug should be stopped and appropriate corrective measures instituted. See ADVERSE REACTIONS.

Ephedrine is contraindicated in patients with known hypersensitivity to sympathomimetic amines and in patients with angle closure glaucoma. It should not be used in patients anesthetized with agents such as cyclopropane or halothane as these agents may sensitize the heart to the arrhythmic action of sympathomimetic drugs.

Ephedrine should not ordinarily be used in those cases where vasopressor drugs may be contraindicated, e. g., in thyrotoxicosis, diabetes, in obstetrics when maternal blood pressure is in excess of 130/80 and in hypertension and other cardiovascular disorders.

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