ENBREL®
(en-brel)
(etanercept) Single-use Prefilled Syringe

Read the Patient Information that comes with ENBREL® Single-use Prefilled Syringe before you start using it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your medical condition or treatment with ENBREL®.

What is the most important information I should know about ENBREL®?

ENBREL® is a medicine that affects your immune system. ENBREL® can lower the ability of your immune system to fight infections. Serious infections, including tuberculosis (TB), have happened in patients taking ENBREL®. Some patients have died from these serious infections.

Before starting ENBREL®, tell your doctor if you:

• think you have an infection
• are being treated for an infection
• have signs of an infection, such as a fever, cough, flu-like symptoms
• have any open sores on your body
• get a lot of infections or have infections that keep coming back
• have diabetes or an immune system problem. People with these conditions have a higher chance for infections.
• have tuberculosis (TB), or if you have been in close contact with someone who has had tuberculosis
• use the medicine Kineretâ (anakinra)
• have or have had hepatitis B

After starting ENBREL®, if you get an infection, any sign of an infection including a fever, cough, flu-like symptoms, or have any open sores on your body, call your doctor right away.

ENBREL® can make you more likely to get infections or make any infection that you may have worse.

What is ENBREL®?

ENBREL® is a medicine called a Tumor Necrosis Factor (TNF) blocker. ENBREL® is used in adults to treat:

• moderately to severely active rheumatoid arthritis (RA). ENBREL® can be used alone or with a medicine called methotrexate.
• psoriatic arthritis. ENBREL® can be used with methotrexate in patients who have not responded well to methotrexate alone.
• ankylosing spondylitis (AS)
• chronic, moderate to severe psoriasis

ENBREL® is used in children with moderately to severely active polyarticular-course juvenile rheumatoid arthritis (JRA) after one or more JRA medicines have been used and not worked well.

ENBREL® can help reduce joint damage, and the signs and symptoms of the above mentioned diseases. People with these diseases have too much protein called tumor necrosis factor (TNF), which is made by your immune system. ENBREL® can reduce the amount of TNF in the body to normal levels and block the damage that too much TNF can cause, but it can also lower the ability of your immune system to fight infections. See “What is the most important information I should know about ENBREL®?” and “What are the possible side effects of ENBREL®?”

Who should not use ENBREL®?

Do not use ENBREL® if you:

• have an infection that has spread through your body (sepsis)
• have ever had an allergic reaction to ENBREL®

What should you tell your doctor before starting ENBREL®?

ENBREL® may not be right for you. Before starting ENBREL®, tell your doctor about all of your health conditions, including if you:

• have an infection. (See “What is the most important information I should know about ENBREL®?”)
• have seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis
• have heart failure
• are scheduled to have surgery
• are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL®. Patients taking ENBREL® should not receive live vaccines.
• are allergic to rubber or latex. The needle cover on the single-use prefilled syringe contains latex.

Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

ENBREL® has not been studied in pregnant women or nursing mothers.

Pregnancy Registry: Amgen has a registry for pregnant women exposed to ENBREL®. The purpose of this registry is to check the health of the pregnant mother and her child. Patients are encouraged to contact the registry themselves or ask their doctors to contact the registry for them by calling 1-877-311-8972.

Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements. Your doctor will tell you if it is okay to take your other medicines while taking ENBREL®. Especially, tell your doctor if you take:

• Kineret® (anakinra). You have a higher chance for serious infections when taking ENBREL® with Kineret®.
• cyclophosphamide. You may have a higher chance for getting certain cancers when taking ENBREL® with cyclophosphamide.

Know the medicines you take. Keep a list of them to show your doctor and pharmacist each time you get a new medicine.

How should I use ENBREL®?

See the section, “How do I prepare and give an injection with ENBREL®Single-use Prefilled Syringe?” at the end of this leaflet for complete instructions for use.

There are 2 types of ENBREL®single-use prefilled syringes:

• The 50 mg single-use prefilled syringe that contains one 50 mg dose of ENBREL®.
• The 25 mg single-use prefilled syringe that contains one 25 mg dose of ENBREL®.

Your doctor will tell you which one to use.

• ENBREL® is given by injection under the skin
• A 50 mg dose can be given as one injection using a 50 mg single-use prefilled syringe or as two injections using 25 mg single-use prefilled syringes. Your doctor will tell you whether the two injections with 25 mg single-use prefilled syringes should be given on the same day once a week or on two different days (3 or 4 days apart) in the same week.
• Make sure you have been shown how to inject ENBREL® before you do it yourself. Someone you know can also help you with your injection.
• Your doctor will tell you how often you should use ENBREL®. This is based on your condition to be treated. Do not use ENBREL® more often than prescribed.
• Do not miss any doses of ENBREL®. Call your doctor if you miss a dose of ENBREL®. Your doctor will tell you when to take your missed dose.

Children must weigh at least 138 pounds to use the ENBREL® 50 mg single-use prefilled syringe. Children who weigh less than 138 pounds should use a different form of ENBREL®. The ENBREL® 25 mg single-use prefilled syringe should not be used in pediatric patients weighing less than 68 pounds.

• Your child's weekly dose of ENBREL® depends on his or her weight. Your child's doctor will tell you which form of ENBREL® to use and how much to give your child.
• ENBREL® has not been studied in children under 2 years of age

What are the possible side effects of ENBREL®?

Serious side effects have happened in people taking ENBREL®, including:

• Serious Infections. See “What is the most important information I should know about ENBREL®?”
• Nervous system problems such as Multiple Sclerosis, seizures, or inflammation of the nerves of the eyes have occurred in rare cases. Symptoms include numbness or tingling, problems with your vision, weakness in your arms and legs, and dizziness.
• Blood problems. In rare cases, your body may not make enough of the blood cells that help fight infections or help stop bleeding. This can lead to death. Symptoms include a fever that doesn't go away, bruising or bleeding very easily, or looking very pale.
• Heart failure including new heart failure or worsening of heart failure you already have. Symptoms include shortness of breath or swelling of your ankles and feet.
• Allergic reactions. Signs of an allergic reaction include a severe rash, a swollen face, or trouble breathing.
• Immune reactions including a lupus-like syndrome. Symptoms include a rash on your face and arms that gets worse in the sun. Symptoms may go away when you stop taking ENBREL®.
• Lymphoma (a type of cancer). People with rheumatoid arthritis or psoriasis may have a higher chance for getting lymphoma.

Call your doctor right away if you develop any of the above symptoms.

Common side effects of ENBREL® include:

• Injection site reactions such as redness, rash, swelling, itching, or bruising. These symptoms usually go away within 3 to 5 days. If you have pain, redness or swelling around the injection site that doesn't go away or gets worse, call your doctor.
• Upper respiratory infections (sinus infections)
• Headaches

These are not all the side effects with ENBREL®. Ask your doctor or pharmacist for more information.

How should I store ENBREL® Single-use Prefilled Syringe?

• Store ENBREL® single-use prefilled syringes in the refrigerator at 36° to 46°F (2° to 8°C).
• Do not freeze. Keep ENBREL® in the original carton to protect from light.
• Keep ENBREL® and all medicines out of the reach of children.

General Information about ENBREL®

Medicines are sometimes prescribed for purposes not mentioned in a Patient Information leaflet. Do not use ENBREL® for a condition for which it was not prescribed. Do not give ENBREL® to other people, even if they have the same condition. It may harm them and it is against the law.

This leaflet summarizes the most important information about ENBREL®. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about ENBREL® that was written for healthcare professionals. For more information call 1-888-4ENBREL (1-888-436-2735).

How do I prepare and give an injection with ENBREL® Single-use Prefilled Syringe?

IMPORTANT: The needle cover on the single-use prefilled syringe contains latex. Tell your doctor if you are allergic to latex.

STEP 1: Setting Up for an Injection

1. Select a clean, well-lit, flat work surface, such as a table.
2. Take the ENBREL® carton containing the prefilled syringes out of the refrigerator and place it on your flat work surface. Remove one prefilled syringe and place it on your work surface. Do not shake the prefilled syringe of ENBREL®. Place the carton containing any remaining prefilled syringes back into the refrigerator (2° to 8°C [36° to 46°F]). If you have any questions about storage, contact your doctor, nurse, or pharmacist for further instructions.
3. Check the expiration date on the prefilled syringe. If the expiration date has passed, do not use the prefilled syringe and contact your pharmacist or call 1-888-4ENBREL (1-888-436-2735) for assistance.
4. Wait 15 to 30 minutes to allow the ENBREL® in the prefilled syringe to reach room temperature. DO NOT remove the needle cover while allowing it to reach room temperature. Do not warm ENBREL® in any other way (for example, do not warm it in a microwave or in hot water).
5. Hold the prefilled syringe with the covered needle pointing down. If bubbles are seen in the syringe, very gently tap the prefilled syringe to allow any bubbles to rise to the top of the syringe. Turn the syringe so that the purple horizontal lines on the barrel are directly facing you. Check to see if the amount of liquid in the syringe falls between the purple lines. The top of the liquid may be curved. If the syringe does not have the right amount of liquid, DO NOT USE THAT SYRINGE. Contact your pharmacist or call 1-888-4ENBREL (1-888-436-2735) for assistance.
6. Assemble the additional supplies you will need for your injection. These include an alcohol swab, a cotton ball or gauze, and a puncture-resistant disposal container.
7. Wash your hands with soap and warm water.
8. Make sure the solution in the prefilled syringe is clear and colorless. You may notice small white particles in the solution. These particles are formed from ENBREL® and this is acceptable. However, do not inject the solution if it is cloudy or discolored, or contains large or colored particles – contact your pharmacist or call 1-888-4ENBREL (1-888-436-2735) for assistance.

STEP 2: Choosing and Preparing an Injection Site

1. Three recommended injection sites for ENBREL® using a prefilled syringe include: (1) the front of the middle thighs; (2) the abdomen, except for the two-inch area right around the navel; and, (3) the outer area of the upper arms.
2. Rotate the site for each injection. Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid areas with scars or stretch marks.
3. If you have psoriasis, you should try not to inject directly into any raised, thick, red, or scaly skin patches (“psoriasis skin lesions”).
4. To prepare the area of skin where ENBREL® is to be injected, wipe the injection site with an alcohol swab. Do not touch this area again before giving the injection.

STEP 3: Injecting ENBREL® Using a Prefilled Syringe

1. Pick up the prefilled syringe from your flat work surface. Hold the barrel of the prefilled syringe with one hand and pull the needle cover straight off.
   When you remove the needle cover, there may be a drop of liquid at the end of the needle; this is normal. Do not touch the needle or allow it to touch any surface. Do not touch or bump the plunger. Doing so could cause the liquid to leak out.
2. Holding the syringe with the needle pointing up, check the syringe for air bubbles. If there are bubbles, gently tap the syringe with your finger until the air bubbles rise to the top of the syringe. Slowly push the plunger up to force the air bubbles out of the syringe.
3. Holding the syringe in one hand like a pencil, use the other hand to gently pinch a fold of skin at the cleaned injection site and hold it firmly.
4. Insert the needle at a slight angle (45 degrees) to the skin. With a quick, “dart-like” motion, insert the needle into the skin.
5. After the needle is inserted, let go of the skin. Pull the plunger back slightly. If blood comes into the syringe, do not inject ENBREL® because the needle has entered a blood vessel. Withdraw the needle and discard it in a puncture-resistant container. Repeat the steps to prepare for an injection using a new prefilled syringe of ENBREL®. Do not use the same prefilled syringe.
6. If no blood appears in the syringe, slowly push the plunger all the way down to inject ENBREL®.
7. When the syringe is empty, pull the needle out of the skin, being careful to keep it at the same angle as inserted. There may be a little bleeding at the injection site. You can press a cotton ball or gauze over the injection site for 10 seconds. Do not rub the injection site. If needed, you may cover the injection site with a bandage.

STEP 4: Disposing of Supplies

The syringe should NEVER be reused. NEVER recap a needle.

Dispose of the used syringe as instructed by your healthcare provider, or by following these steps:

• Do not throw the used syringe in the household trash or recycle.
• Place the used syringe in a hard plastic disposal container with a screw-on cap or a metal container with a plastic lid, such as a coffee can, labeled “used syringes.” If a metal container is used, cut a small hole in the plastic lid and tape the lid to the metal container. If a hard plastic container is used, always screw the cap on tightly after each use. Do not use glass or clear plastic containers. Puncture-resistant containers may also be purchased at your local pharmacy.
• When the container is full, tape around the cap or lid to make sure the cap or lid does not come off.
• You should always check first with your healthcare provider for instructions on how to properly dispose of a filled disposal container. There may be special state and local laws for disposing of used needles and syringes. Do not throw the disposal container in household trash. Do not recycle.
• Always keep the container out of the reach of children.

What are the ingredients in ENBREL® Single-use Prefilled Syringe?

Active Ingredient: etanercept

Inactive Ingredients: sucrose, sodium chloride, L-arginine hydrochloride, sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous

A healthcare provider familiar with ENBREL® should answer all questions. A toll-free information service is also available: 1-888-4ENBREL (1-888-436-2735).

Patient Information

ENBREL® (en-brel)
(etanercept)
Single-use Prefilled SureClick™ Autoinjector

Read the Patient Information that comes with ENBREL® Single-use Prefilled SureClick™ Autoinjector before you start using it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your medical condition or treatment with ENBREL®.

What is the most important information I should know about ENBREL®?

ENBREL® is a medicine that affects your immune system. ENBREL® can lower the ability of your immune system to fight infections. Serious infections, including tuberculosis (TB), have happened in patients taking ENBREL®. Some patients have died from these serious infections.

Before starting ENBREL®, tell your doctor if you:

• think you have an infection
•  are being treated for an infection
• have signs of an infection, such as a fever, cough, flu-like symptoms
• have any open sores on your body
• get a lot of infections or have infections that keep coming back
• have diabetes or an immune system problem. People with these conditions have a higher chance for infections.
• have tuberculosis (TB), or if you have been in close contact with someone who has had tuberculosis
• use the medicine Kineret® (anakinra)
• have or have had hepatitis B

After starting ENBREL®, if you get an infection, any sign of an infection including a fever, cough, flu-like symptoms, or have any open sores on your body, call your doctor right away.

ENBREL® can make you more likely to get infections or make any infection that you may have worse.

What is ENBREL®?

ENBREL® is a medicine called a Tumor Necrosis Factor (TNF) blocker. ENBREL® is used in adults to treat:

•  moderately to severely active rheumatoid arthritis (RA). ENBREL® can be used alone or with a medicine called methotrexate.
•  psoriatic arthritis. ENBREL® can be used with methotrexate in patients who have not responded well to methotrexate alone.
•  ankylosing spondylitis (AS)
•  chronic, moderate to severe psoriasis

ENBREL® is used in children with moderately to severely active polyarticular-course juvenile rheumatoid arthritis (JRA) after one or more JRA medicines have been used and not worked well.

ENBREL® can help reduce joint damage, and the signs and symptoms of the above mentioned diseases. People with these diseases have too much protein called tumor necrosis factor (TNF), which is made by your immune system. ENBREL® can reduce the amount of TNF in the body to normal levels and block the damage that too much TNF can cause, but it can also lower the ability of your immune system to fight infections. See “What is the most important information I should know about ENBREL®?” and “What are the possible side effects of ENBREL®?”

Children must weigh at least 138 pounds to use ENBREL® single-use prefilled Sureclick™ autoinjector. Children who weigh less than 138 pounds should use a different form of ENBREL®.

ENBREL® has not been studied in children under 2 years of age.

Who should not use ENBREL®?

Do not use ENBREL® if you:

• have an infection that has spread through your body (sepsis)
• have ever had an allergic reaction to ENBREL®

What should you tell your doctor before starting ENBREL®?

ENBREL® may not be right for you. Before starting ENBREL®, tell your doctor about all of your health conditions, including if you:

•        have an infection. (See “What is the most important information I should know about ENBREL®?”)
•        have seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis
•        have heart failure
•        are scheduled to have surgery
•        are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL®. Patients taking ENBREL® should not receive live vaccines.
•        are allergic to rubber or latex. The needle shield on the single-use prefilled SureClick™ autoinjector contains latex.

Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

ENBREL® has not been studied in pregnant women or nursing mothers.

Pregnancy Registry: Amgen has a registry for pregnant women exposed to ENBREL®. The purpose of this registry is to check the health of the pregnant mother and her child. Patients are encouraged to contact the registry themselves or ask their doctors to contact the registry for them by calling 1-877-311-8972.

Tell your doctor about all the medicines you take including prescription and nonprescription medicines, vitamins and herbal supplements. Your doctor will tell you if it is okay to take your other medicines while taking ENBREL®. Especially, tell your doctor if you take:

• Kineret® (anakinra). You have a higher chance for serious infections when taking ENBREL® with Kineret®.
•  cyclophosphamide. You may have a higher chance for getting certain cancers when taking ENBREL® with cyclophosphamide.

Know the medicines you take. Keep a list of them to show your doctor and pharmacist each time you get a new medicine.

How should I use ENBREL®?

See the section, “How do I prepare and give an injection with ENBREL® Single-use Prefilled SureClick™ Autoinjector?” at the end of this leaflet for complete instructions for use.

• A single-use prefilled SureClick™ autoinjector contains one 50 mg dose of ENBREL®.
• ENBREL® is given by injection under the skin.
• Make sure you have been shown how to inject ENBREL® before you do it yourself. Someone you know can also help you with your injection.
• Your doctor will tell you how often you should use ENBREL®. This is based on your condition to be treated Do not use ENBREL® more often than prescribed.
• Your child's weekly dose of ENBREL® depends on his or her weight. Your child's doctor will tell you which form of ENBREL® to use and how much to give your child.
• Do not miss any doses of ENBREL® Call your doctor if you miss a dose of ENBREL®. Your doctor will tell you when to take your missed dose.

What are the possible side effects of ENBREL®?

Serious side effects have happened in people taking ENBREL®, including:

•  Serious Infections. See “What is the most important information I should know about ENBREL®?”
• Nervous system problems such as Multiple Sclerosis, seizures, or inflammation of the nerves of the eyes have occurred in rare cases. Symptoms include numbness or tingling, problems with your vision, weakness in your arms and legs, and dizziness.
• Blood problems. In rare cases, your body may not make enough of the blood cells that help fight infections or help stop bleeding. This can lead to death. Symptoms include a fever that doesn't go away, bruising or bleeding very easily, or looking very pale.
• Heart failure including new heart failure or worsening of heart failure you already have. Symptoms include shortness of breath or swelling of your ankles and feet.
• Allergic reactions. Signs of an allergic reaction include a severe rash, a swollen face, or trouble breathing.
• Immune reactions including a lupus-like syndrome. Symptoms include a rash on your face and arms that gets worse in the sun. Symptoms may go away when you stop taking ENBREL®.
• Lymphoma (a type of cancer). People with rheumatoid arthritis or psoriasis may have a higher chance for getting lymphoma.

Call your doctor right away if you develop any of the above symptoms.

Common side effects of ENBREL® include:

• Injection site reactions such as redness, rash, swelling, itching, or bruising. These symptoms usually go away within 3 to 5 days. If you have pain, redness or swelling around the injection site that doesn't go away or gets worse, call your doctor.
• Upper respiratory infections (sinus infections)
• Headaches

These are not all the side effects with ENBREL®. Ask your doctor or pharmacist for more information.

How should I store ENBREL® Single-use Prefilled SureClick™ Autoinjector?

•  Store ENBREL® single-use prefilled SureClick™ autoinjector in the refrigerator at 36° to 46° F (2° to 8° C).
• Do not freeze. Keep ENBREL® in the original carton to protect from light.
• Keep ENBREL® and all medicines out of the reach of children.

General Information about ENBREL®

Medicines are sometimes prescribed for purposes not mentioned in a Patient Information leaflet. Do not use ENBREL® for a condition for which it was not prescribed. Do not give ENBREL® to other people, even if they have the same condition. It may harm them and it is against the law.

This leaflet summarizes the most important information about ENBREL®. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about ENBREL® that was written for healthcare professionals. For more information call 1-888-4ENBREL (1-888-436-2735).

How do I prepare and give an injection with ENBREL® Single-use Prefilled SureClick™ Autoinjector?

IMPORTANT: The needle shield on the single-use prefilled SureClick™ autoinjector contains latex. Tell your doctor if you are allergic to latex.

Setting Up for an Injection

• Remove one single-use prefilled SureClick™ autoinjector from the carton. Do not shake the autoinjector. Place the carton containing any remaining autoinjectors back into the refrigerator (2° to 8°C [36° to 46°F]). Do not freeze. If you have any questions about storage, contact your doctor, nurse, or pharmacist for further instructions.
• Make sure the solution in the autoinjector is clear and colorless by looking through the inspection window. You may notice small white particles in the solution. These particles are formed from ENBREL® and this is acceptable. However, do not inject the solution if it is cloudy or discolored, or contains large or colored particles –contact your pharmacist or call 1-888-4ENBREL (1-888-436-2735) for assistance.
• Check the expiration date on the autoinjector. If the expiration date has passed, do not use the autoinjector and contact your pharmacist or call 1-888-4ENBREL (1-888-436-2735) for assistance.
• DO NOT remove the white needle shield from the autoinjector until you are ready to inject. NEVER recap the needle.
• For a more comfortable injection, wait 15 to 30 minutes to allow the autoinjector to reach room temperature. DO NOT remove the white needle shield while allowing it to reach room temperature. Do not warm ENBREL® in any other way (for example, do not warm it in a microwave or in hot water).
• Assemble the additional supplies you will need for your injection. These include an alcohol swab and a cotton ball or gauze. Ensure that you have a puncture-resistant disposal container available (see “Disposing of Supplies” section). Wash your hands with soap and warm water.

Choosing and Preparing an Injection Site

•  The recommended injection site for ENBREL® using a SureClick™ autoinjector is the front of the middle thighs. You can also use the abdomen, except for the two-inch area right around the navel. If someone else is giving you the injection, you can use the outer area of the upper arms.
• Rotate the site for each injection. Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid areas with scars or stretch marks.
• If you have psoriasis, you should try not to inject directly into any raised, thick, red, or scaly skin patches or lesions.
•  To prepare the area of skin where ENBREL® is to be injected, wipe the injection site with an alcohol swab Do not touch this area again before giving the injection.

Injecting ENBREL® Using a Single-use Prefilled SureClick™ Autoinjector

1. Pick up the SureClick™ autoinjector and pull the white needle shield straight off. Do not twist it off, and do not recap the white needle shield, as either of these may damage the needle inside the autoinjector.
2. Without pressing the purple button, place the open end of the autoinjector on the injection site at a right angle (90o) and push the safety needle cover firmly against the skin to unlock. Continue to hold down.
3. To start the injection, press once and release the purple button on top. You will hear the first ‘click.' Do not lift the autoinjector.
4. After the second ‘click' (or a count of 15 seconds) the injection is complete. Once you hear the second click, lift the autoinjector from the injection site. The safety needle cover on the autoinjector will automatically extend to cover the needle.

After Injection

• Check to make sure the autoinjector's inspection window is purple. A purple inspection window indicates that the autoinjector has worked properly. If the inspection window is not purple, do not try to use the autoinjector again. Call 1-888-4ENBREL (1-888-436-2735).
• There may be a little bleeding at the injection site. You can press a cotton ball or gauze over the injection site for 10 seconds. Do not rub the injection site. If needed, you may cover the injection site with a bandage.

Disposing of Supplies

The SureClick™ autoinjector should NEVER be reused.

Dispose of the used autoinjector as instructed by your healthcare provider, or by following these steps:

• Do not throw the used autoinjector in the household trash or recycle.
• Place the used autoinjector in a hard plastic disposal container with a screw-on cap or a metal container with a plastic lid, such as a coffee can, labeled “used syringes.” If a metal container is used, cut a small hole in the plastic lid and tape the lid to the metal container. If a hard plastic container is used, always screw the cap on tightly after each use. Do not use glass or clear plastic containers. Puncture-resistant containers may also be purchased at your local pharmacy.
• When the container is full, tape around the cap or lid to make sure the cap or lid does not come off.
• You should always check first with your healthcare provider for instructions on how to properly dispose of a filled disposal container. There may be special state and local laws for disposing of used needles and syringes, including autoinjectors. Do not throw the disposal container in household trash. Do not recycle.
• Always keep the container out of the reach of children.

What are the ingredients in ENBREL® Single-use Prefilled SureClick™ Autoinjector?

Active Ingredient: etanercept

Inactive Ingredients: sucrose, sodium chloride, L-arginine hydrochloride, sodium phosphate monobasic monohydrate, sodium phosphate dibasic anhydrous

A healthcare provider familiar with ENBREL® should answer all questions. A toll-free information service is also available: 1-888-4ENBREL (1-888-436-2735).

Bookmark this page: