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Pepcid

Clinical Pharmacology
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Clinical Pharmacology

Pepcid

Five published studies (Table 8) examined the effect of famotidine on gastric pH and duration of acid suppression in pediatric patients. While each study had a different design, acid suppression data over time are summarized as follows:

Table 8


Dosage Route Effecta Number of Patients
(age range)
0.5 mg/kg, single dose I.V. gastric pH > 4 for 19.5 hours (17.3, 21.8c) 11 (5-19 days)
0.3 mg/kg, single dose I.V. gastric pH > 3.5 for 8.7 &plsumn; 4.7b hours 6 (2-7 years)
0.4-0.8 mg/kg I.V. gastric pH > 4 for 6-9 hours 18 (2-69 months)
0.5 mg/kg, single dose I.V. a > 2 pH unit increase above baseline in gastric pH for > 8 hours 9 (2-13 years)
0.5 mg/kg b.i.d. I.V. gastric pH > 5 for 13.5 ± 1.8bhours 4 (6-15 years)
0.5 mg/kg b.i.d. oral gastric pH > 5 for 5.0 ± 1.1bhours 4 (11-15 years)
a Values reported in published literature.
b Means ± SD.
c Mean (95% confidence interval).

The duration of effect of famotidine I.V. 0.5 mg/kg on gastric pH and acid suppression was shown in one study to be longer in pediatric patients < 1 month of age than in older pediatric patients. This longer duration of gastric acid suppression is consistent with the decreased clearance in pediatric patients < 3 months of age (see Table 6).

Brand Name: Pepcid
Generic Name: Famotidine
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