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FDG

Overdosage & Contraindications
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OVERDOSE

Overdoses of [18F]FDG have not been reported. See Radiation Dosimetry Section for related information.

RADIATION DOSIMETRY

The estimated absorbed radiation doses to an average human adult (70 kg) from intravenous injection of 185 MBq (5 mCi) and 370 MBq (10 mCi) of [18F]FDG are shown in Table 4. These estimates were calculated based on human 1 data and using the data published by the International Commission on Radiological Protection 2 for [18F]FDG.

Table 4. Estimated Absorbed Radiation Doses after intravenous administration of 2-deoxy-2 - [18F]fluoro- D -glucose, [18F]FDG to a 70 kg patient.

Organ

mGy/185MBq

rads/5mCi

mGy/370MBq

rads/10 mCi

Bladder Wall

31.45

3.15

62.90

6.29

1Bladder*

11.00

1.10

22.00

2.20

1Bladder**

22.00

2.20

44.00

4.40

Heart

12.03

1.20

24.05

2.41

Brain

4.81

0.48

9.62

0.96

Kidneys

3.88

0.39

7.77

0.78

Uterus

3.70

0.37

7.40

0.74

Ovaries

2.78

0.28

5.55

0.56

Testes

2.78

0.28

5.55

0.56

Adrenals

2.59

0.26

5.18

0.52

Sm Intestine

2.40

0.24

4.81

0.48

ULI wall

2.40

0.24

4.81

0.48

LLI wall

2.96

0.30

5.92

0.59

Stomach wall

2.22

0.22

4.44

0.44

Liver

2.22

0.22

4.44

0.44

Pancreas

2.22

0.22

4.44

0.44

Spleen

2.22

0.22

4.44

0.44

Breast

2.04

0.20

4.07

0.41

Lungs

2.04

0.20

4.07

0.41

Red Marrow

2.04

0.20

4.07

0.41

Other Tissue

2.04

0.20

4.07

0.41

Bone Surfaces

1.85

0.18

3.70

0.37

Thyroid

1.79

0.18

3.59

0.36

*With void 1 hour after administration

**With void 2 hours after administration

The [18F]FDG Effective dose equivalent (Adult) 2 is 0.027 mSv/MBq.

1. Jones, S.C. , Alavi, A., Christman, D., Montanez, I., Wolf, A.P., and Reivich, M. (1982). The Radiation Dosimetry of 2-F-18 fluoro-2-deoxy- D -glucose in man. J. Nucl. Med. 23, 613-617.

2. ICRP Publication 53, Volume 18, No. 1-4, 1987, page 76.

CONTRAINDICATIONS

None known

Brand Name: FDG
Generic Name: Fluorodeoxyglucose F18 Injection
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