Gardasil (Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine) clinical pharmacology - prescription drugs and medications at RxList

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Gardasil

Clinical Pharmacology

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Clinical Pharmacology

Gardasil

Table 4 compares anti-HPV GMTs 1 month Postdose 3 among subjects who received Dose 2 between Month 1 and Month 3 and subjects who received Dose 3 between Month 4 and Month 8 (Table 4).

Table 4
Summary of GMTs for Variation of Dosing Regimen

Variation of Dosing Regimen	Anti-HPV 6		Anti-HPV 11		Anti-HPV 16		Anti-HPV 18
Variation of Dosing Regimen	N	GMT (95% CI)	N	GMT (95% CI)	N	GMT (95% CI)	N	GMT (95% CI)
Dose 2
Early*	883	570.9 (542.2, 601.2)	888	824.6 (776.7, 875.5)	854	2625.3 (2415.1, 2853.9)	926	517.7 (482.9, 555.0)
On Time*	1767	552.3 (532.3, 573.1)	1785	739.7 (709.3, 771.5)	1737	2400.0 (2263.9, 2544.3)	1894	473.9 (451.8, 497.1)
Late*	313	447.4 (405.3, 493.8)	312	613.9 (550.8, 684.2)	285	1889.7 (1624.4, 2198.5)	334	388.5 (348.3, 433.3)
Dose 3
Early**	495	493.1 (460.8, 527.8)	501	658.9 (609.5, 712.2)	487	2176.6 (1953.4, 2425.3)	521	423.4 (388.8, 461.2)
On Time**	2081	549.6 (531.1, 568.8)	2093	752.8 (723.8, 782.9)	2015	2415.0 (2286.3, 2550.9)	2214	486.0 (464.7, 508.2)
Late**	335	589.0 (537.0, 645.9)	339	865.3 (782.6, 956.7)	326	2765.9 (2408.7, 3176.2)	361	498.5 (446.2, 557.0)
Early = 36 to 50 days Postdose 1; On-Time = 51 to 70 days Postdose 1; Late = 71 to 84 days Postdose 1. *Early = 80 to 105 days Postdose 2; On-Time = 106 to 137 days Postdose 2; Late = 138 to 160 days Postdose 2. Note: GMT = Geometric mean titer in mMU/mL (mMU = milli-Merck units.)