It should be noted that lengths of administration and dosages may change based on the severity of the symptoms and the type of problem.

The clinical efficacy of the dosages listed below need more dose-related studies to be substantiated however, they are traditionally appropriate.

Ginseng may need to be taken for a period of time before it’s effects are realized. It has been said that it may take from one week to a month before the effects of Ginseng usage may be felt.

Traditionally, many herbalist have recommended a regime that consists of short breaks from ginseng usage if the herb is being used over an extended period. These breaks in usage are usually 2-3 weeks longs and may be substantiated by some studies that have been conducted to date (see Adverse Effects and Warnings).

The below table consists of common average recommended dosages for ginseng usage. However, as an adjunct to this low dosages are usually 0.5–1.0 grams/day – and high dosages 3.0–4.5 grams/day with the avgerage dosage for ginseng usage being 1 to 2 grams a day.

Dosage Studies:

A total of 227 volunteers received daily oral capsule doses of either placebo or 100 mg of standardized ginseng extract Ginsana G 115 for a period of 12 weeks, within which time they received an anti influenza polyvalent vaccination. "As a result the frequency of influenza or common cold between weeks 4 and 12 was 42 cases in the placebo group whereas it was only 15 cases in the G115 group, the difference being statistically highly significant…. Natural killer (NK) activity levels at weeks 8 and 12 were nearly twice as high in the G115 group as compared to the placebo group." ¹³⁹

"…results of this study do not support an ergogenic effect on peak aerobic exercise performance following a 3-week supplementation period of 200 mg 7% Panax ginseng in healthy young adults with moderate exercise capacities and unrestricted diets." ¹⁰⁵

"In an RDBPCT, college-aged volunteers who took 100 mg of ginseng twice daily for 12 weeks experienced a statistical improvement in the speed at which they were able to perform mathematical calculations, but did not experience improvement in motor function or other cognitive functions. No adverse effects were reported. It is concluded that G 115 may be superior to placebo in improving certain psychomotor functions in healthy subjects." ¹⁰⁶

How Supplied:

Internal use - It is usually taken as a comminuted drug, herb powder, Liquid or solid preparation

External use - Liquid and semi-solid preparations

REFERENCES

1. Song YN: "Botanical origin of shenye in Sichuan Province.[Chinese]", Chung Yao Tung Pao, v11, n10, Oct 1986. Hu SY, "A contribution to our knowledge of ginseng", Am J Chin Med, v5, n1, Spring 1977. Song YN, "[Classification of the genus Panax]. [Chinese]" Chung Yao Tung Pao, v11, n9, Sep 1986
2. Song YN, Xie CK: "A taxonomical study on plants of the genus Panax in Sichuan. [Chinese]", Hua Hsi I Ko Ta Hsueh Hsueh Pao, v17, n4, Dec 1986
3. Samukawa K, Yamashita H, Matsuda H, Kubo M: Simultaneous analysis of ginsenosides of various ginseng radix by HPLC, [Japanese], Yakugaku Zasshi, v115, n3, Mar 1995
4. Liu H, Liu T, Ren F, Hu B: Amino acid analysis of the main organs during different growing periods of Panax ginseng C. A. Meyer, [Chinese], Chung Kuo Chung Yao Tsa Chih, v15, n12, Dec 1990
5. Liu M, Li R, Liu M: Observation on the annual and seasonal changes of anatomic characteristics of the main root of Panax ginseng C. A. Meyer, [Chinese], Chung Kuo Chung Yao Tsa Chih, v15, n1, Jan 1990
6. Wang TS: "Effect of different soil water conditions on the growth and physiology of Panax ginseng C. A. Meyer [Chinese]", Chung Kuo Chung Yao Tsa Chih, v15, n1, Jan 1990. Chung Yao Tung Pao, v12, n7, Jul 1987
7. Kitagawa I, Taniyama T, Shibuya H, Noda T, Yoshikawa M: Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root. [Japanese], Yakugaku Zasshi, v107, n7, Jul 1987
8. Li X, Guo R, Li L: Pharmacological variations of Panax ginseng C. A. Meyer during processing, [Chinese], Chung Kuo Chung Yao Tsa Chih, v16, n1, Jan 1991
9. Yoshikawa M, Fukuda Y, Hatakeyama S, Murakami N, Yamahara J, Taniyama T, Hayashi T, Kitagawa I: Chemical fluctuation of the constituents during the drying of Ginseng radix and Ginseng radix Rubra. Crude drug processing by far-infrared treatment, [Japanese], Yakugaku Zasshi, v113, n6, Jun 1993
10. Mizuno M, Yamada J, Terai H, Kozukue N, Lee YS, Tsuchida H: Differences in immunomodulating effects between wild and cultured Panax ginseng., Biochem Biophys Res Commun, v200, n3, May 16 1994
11. Choi JE, Kang SK, Kim HG, Lee YB, Shim IY, Kang KK: The physical map of the chloroplast DNA from Korean ginseng (Panax ginseng C. A. Meyer), Mol Cells, v7, n1, Feb 28 1997
12. Fushimi H, Komatsu K, Isobe M, Namba T: Application of PCR-RFLP and M.S. analyses on 18S ribosomal RNA gene sequence for the identification of three Ginseng drugs, Biol Pharm Bull, v20, n7, Jul 1997
13. Wen J, Zimmer EA: Phylogeny and biogeography of Panax L. (the ginseng genus, araliaceae): inferences from ITS sequences of nuclear ribosomal DNA, Mol Phylogenet Evol, v6, n2, Oct 1996
14. Choi JE, Kang SK, Kim HG, Lee YB, Shim IY, Kang KK : The physical map of the chloroplast DNA from Korean ginseng (Panax ginseng C. A. Meyer), Mol Cells 1997 Feb 28;7(1):136-Castleman M. Ginseng. Herb Q. 1990;48:17-24. 9
15. Lawrence Review of Natural Products. Ginseng. St Louis, Mo: Facts and Comparisons; 1990
16. Mark Blumenthal: The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines, American Botanical Council, 1998, ISBN 096555550X
17. Gillis CN: Panax ginseng pharmacology: a nitric oxide link? [Review] [50 refs], Biochem Pharmacol, v54, n1, Jul 1 1997
18. US Pharmacopeia Press Release: USP Publishes Nine New Botanical Monographs. The Standard of Quality in Promoting the Public Health, November 2, 1998
19. US Pharmacopeia Press Release: AMA Recognizes USP Role in Establishing Quality of Herbal Product, December 16, 1998
20. Bi KS, Wang X, Luo X: Quality assessment of ginseng by chemical fuzzy pattern recognition. [Chinese], Yao Hsueh Hsueh Pao, v27, n1, 1992
21. Shaw PC, But PP: Authentication of Panax species and their adulterants by random-primed polymerase chain reaction, Planta Med, v61, n5, Oct 1995
22. Liu CX, Xiao PG, "Recent advances on ginseng research in China. [Review] [57 refs]", J Ethnopharmacol, v36, n1, Feb 1992
23. Duke, James A: Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants, Boca Raton, FL. CRC Press, 1992. ISBN 0849371929
24. Liu H, Liu T, Ren F, Hu B: Amino acid analysis of the main organs during different growing periods of Panax ginseng C.A. Mey, [Chinese]", Chung Kuo Chung Yao Tsa Chih, v15, n12, Dec 1990
25. Nah JJ; Kim SK; Kim SC; Nam KY; Jung DW; Nah SY; Yoon SR: Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay; Chem Pharm Bull (Tokyo) 1998 Jul;46(7):1144-7
26. Chen ZK; Fan CX; Ye YH; Yang L: Isolation and characterization of a group of oligopeptides related to oxidized glutathione from the root of Panax ginseng. Jiang Q; Xing QY, J Pept Res 1998 Aug;52(2):137-42
27. Park JD; Lee YH; Kim SI : Ginsenoside Rf2, a new dammarane glycoside from Korean red ginseng (Panax ginseng), Arch Pharm Res 1998 Oct;21(5):615-7
28. Riva S; Monti D; Luisetti M; Danieli B: Enzymatic modification of natural compounds with pharmacological properties, Ann N Y Acad Sci 1998 Dec 13;864:70-80
29. Mogil JS; Shin YH; McCleskey EW; Kim SC; Nah SY: Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice, Brain Res 1998 May 11;792(2):218-28
30. Akao T; Kanaoka M; Kobashi K: Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral, Biol Pharm Bull 1998 Mar;21(3)245-9
31. Wada O; Nagahashi M: Germanium poisoning caused by health food. Canada Inst. for Scientific and Technical Information, Ottawa (Ontario). Govt Reports Announcements & Index (GRA&I), Issue 03, 1991 NTIS/MIC-90-00578
32. Baek NI, Kim DS, Lee YH, Park JD, Lee CB, Kim SI: Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng, Planta Med, v62, n1, Feb 1996
33. Kim DS, Chang YJ, Zedk U, Zhao P, Liu YQ, Yang CR: Dammarane saponins from Panax ginseng, Phytochemistry, v40, n5, Nov 1995
34. Tomoda M, Hirabayashi K, Shimizu N, Gonda R, Ohara N: The core structure of ginsenan PA, a phagocytosis-activating polysaccharide from the root of Panax ginseng, Biol Pharm Bull, v17, n9, Sep 1994
35. Tomoda M, Hirabayashi K, Shimizu N, Gonda R, Ohara N, Takada K: Characterization of two novel polysaccharides having immunological activities from the root of Panax ginseng., Biol Pharm Bull, v16, n11, Nov 1993
36. Tomoda M, Takeda K, Shimizu N, Gonda R, Ohara N, Takada K, Hirabayashi K: Characterization of two acidic polysaccharides having immunological activities from the root of Panax ginseng, Biol Pharm Bull, v16, n1, Jan 1993
37. Wang JY, Li XG, Zheng YN: Isolation and identification of malonyl-ginsenosides from the fresh root of Panax ginseng C. A. Meyer, [Chinese], Chung Kuo Chung Yao Tsa Chih, v18, n2, Feb 1993
38. Fujimoto Y, Satoh M, Takeuchi N, Kirisawa M: Synthesis and absolute configurations of the cytotoxic polyacetylenes isolated from the callus of Panax ginseng [published erratum appears in Chem Pharm Bull (Tokyo) 1990 Dec;38(12):3503], Chem Pharm Bull (Tokyo), v38, n6, Jun 1990
39. Xu DM, Xu YJ: Recent advances in studying the chemical constituents of Panax ginseng C.A. Mey, [Chinese], Chung Kuo Chung Yao Tsa Chih, v14, n6, Jun 1989
40. Yip TT, Lau CN, But PP, Kong YC: Quantitative analysis of ginsenosides in fresh Panax ginseng, Am J Chin Med, v13, n1-4, 1985
41. Yip TT, Lau CN, Kong YC, Yung KH, Kim JH, Woo WS: Ginsenoside compositions of Panax ginseng C. A. Meyer tissue culture and juice, Am J Chin Med, v13, n1-4, 1985
42. Kaku T, Kawashima Y: Isolation and characterization of ginsenoside-Rg2, 20R-prosapogenin, 20S-prosapogenin and delta 20-prosapogenin. Chemical studies on saponins of Panax ginseng C. A. Meyer, Third report., Arzneimittelforschung, v30, n6, 1980
43. Hou JP: The chemical constituents of ginseng plants Comp Med East West 1977 Summer;5(2):123-45
44. Shin KS, Kiyohara H, Matsumoto T, Yamada H: Rhamnogalacturonan II from the leaves of Panax ginseng C. A. Meyer as a macrophage Fc receptor expression-enhancing polysaccharide, Carbohydr Res, v300, n3, May 16 1997
45. Kiyohara H, Hirano M, Wen XG, Matsumoto T, Sun XB, Yamada H: Characterisation of an anti-ulcer pectic polysaccharide from leaves of Panax ginseng C. A. Meyer., Carbohydr Res, v263, n1, Oct 3 1994
46. Zhao YQ, Yuan CL: Chemical constituents of the fruit of Panax ginseng C. A. Meyer [Chinese], Chung Kuo Chung Yao Tsa Chih, v18, n5, May 1993
47. Zhao Y, Yuan C, Lu H: Isolation and identification of 20(R)-ginsenoside-Rh2 (an anti-cancer constituent) from the fruits of Panax ginseng. C. A. Meyer, [Chinese]", Chung Kuo Chung Yao Tsa Chih, v16, n11, Nov 1991
48. Gao QP, Kiyohara H, Yamada H: Further structural studies of anti-complementary acidic heteroglycans from the leaves of Panax ginseng C. A. Meyer,, Carbohydr Res, v196, Feb 25
49. Zhao YQ, Yuan CL, Fu YQ, Wei XJ, Zhu HJ, Chen YJ, Wu LJ, Li X: Chemical studies of minor triterpene compounds isolated from the stems and leaves of Panax ginseng C. A. Meyer [Chinese] Yao Hsueh Hsueh Pao, v25, n4, 1990.1990, pp. 111-25.aves of Panax ginseng C. A. Meyer]. [Chinese]", Yao Hsueh Hsueh Pao, v25, n5, 1990
50. Zhang SL, Chen YJ, Cui CB, He GX, Xu SX, Pei YP, Yao XS, Zhu TR,:A new minor saponin from the leaves of Panax ginseng C. A. Meyer. [Chinese] Yao Hsueh Hsueh Pao, v24, n11, 1989
51. Pearce PT, Zois I, Wynne KN, Funder JW: Panax ginseng and Eleuthrococcus senticosus extracts--in vitro studies on binding to steroid receptors, Endocrinol Jpn 1982 Oct;29(5):567-73
52. Salvati G, Genovesi G, Marcellini L, et al: Effects of Panax ginseng C. A. Meyer saponins on male fertility. Panminerva Med. 1996;38:249-254
53. Nakajima S; Uchiyama Y; Yoshida K; Mizukawa H; Haruki E: The effects of ginseng radix rubra on human vascular endothelial cells, Am J Chin Med 1998;26(3-4):365-73
54. Kim YC; Kim SR; Markelonis GJ; Oh TH: Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration [published erratum appears in J Neurosci Res 1998 Oct 1;54(1):123], J Neurosci Res 1998 Aug 15;53(4):426-32
55. Abdrasilov BS, Elemesov RE, Kim IuA, Pak Khva Din: Action of triterpene glycosides of the dammarane series and their aglycones on lipid membranes, Antibiot Khimioter 1995 Nov-Dec 40:11-12 16-9,
56. Kim DH; Jung JS; Suh HW; Huh SO; Min SK; Son BK; Park JH; Kim ND; Kim YH; Song DK: Inhibition of stress-induced plasma corticosterone levels by ginsenosides in mice: involvement of nitric oxide. Neuroreport 1998 Jul 13;9(10):2261-4
57. Kim HS; Lee JH; Goo YS; Nah SY: Effects of ginsenosides on Ca2+ channels and membrane capacitance in rat adrenal chromaffin cells, Brain Res Bull 1998 Jun;46(3):245-51
58. Kim HS; Hong YT; Jang CG: Effects of the ginsenosides Rg1 and Rb1 on morphine-induced hyperactivity and reinforcement in mice., J Pharm Pharmacol 1998 May;50(5):555-60
59. Akao T; Kida H; Kanaoka M; Hattori M; Kobashi K: Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng J Pharm Pharmacol 1998 Oct;50(10):1155-60
60. Scaglione F; Ferrara F; Dugnani S; Falchi M; Santoro G; Fraschini F: Immunomodulatory effects of two extracts of Panax ginseng C. A. Meyer. Drugs Exp Clin Res 1990;16(10):537-42
61. Kim HS; Hong YT; Oh KW; Seong YH; Rheu HM; Cho DH; Oh S; Park WK; Jang CG: Inhibition by ginsenosides Rb1 and Rg1 of methamphetamine-induced hyperactivity, conditioned place preference and postsynaptic dopamine receptor supersensitivity in mice Gen Pharmacol 1998 May;30(5):783-9
62. Akao T; Kanaoka M; Kobashi K Appearance of compound K, a major metabolite of ginsenoside Rb1 by intestinal bacteria, in rat plasma after oral,, Biol Pharm Bull 1998 Mar;21(3):245-9
63. Wang LC; Lee TF: Effect of ginseng saponins on exercise performance in non-trained rats., Planta Med 1998 Mar;64(2):130-3
64. Kim KH; Lee YS; Jung IS; Park SY; Chung HY; Lee IR; Yun YS: Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2. Planta Med 1998 Mar;64(2):110-5
65. Sonoda Y; Kasahara T; Mukaida N; Shimizu N; Tomoda M; Takeda: Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng. T Immunopharmacology 1998 Jan;38(3):287-94
66. Sohn J; Lee CH; Chung DJ; Park SH; Kim I: Hwang WI Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells. Exp Mol Med 1998 Mar 31;30(1):47-51
67. Wang BX, Yang M, Jin YL, Cui ZY, Wang Y Yao: Studies on the hypoglycemic effect of ginseng polypeptide. Hsueh Hsueh Pao 1990;25(6):401-5 [Article in Chinese]
68. Kaku T, Miyata T, Uruno T, Sako I, Kinoshita A: Chemico-pharmacological studies on saponins of Panax ginseng C. A. Meyer. II. Pharmacological part. Arzneimittelforschung 1975 Apr;25(4):539-47
69. Chen X, Salwinski S, Lee TJ: "Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway.", Clin Exp Pharmacol Physiol, v24, n12, Dec 1997
70. Kim HJ, Chun YJ, Park JD, Kim SI, Roh JK, Jeong TC: "Protection of rat liver microsomes against carbon tetrachloride-induced lipid peroxidation by red ginseng saponin through cytochrome P450 inhibition.", Planta Med, v63, n5, Oct 1997
71. Chen X: "Cardiovascular protection by ginsenosides and their nitric oxide releasing action., Clin Exp Pharmacol Physiol, v23, n8, Aug 1996
72. Park HJ, Lee JH, Song YB, Park KH: "Effects of dietary supplementation of lipophilic fraction from Panax ginseng on cGMP and cAMP in rat platelets and on blood coagulation.", Biol Pharm Bull, v19, n11, Nov 1996
73. Rimar S, Lee-Mengel M, Gillis CN: "Pulmonary protective and vasodilator effects of a standardized Panax ginseng preparation following artificial gastric digestion.", Pulm Pharmacol, v9, n4, Aug 1996
74. Kim HS, Kang JG, Seong YH, Nam KY, Oh KW: "Blockade by ginseng total saponin of the development of cocaine induced reverse tolerance and dopamine receptor supersensitivity in mice.", Pharmacol Biochem Behav, v50, n1, Jan 1995
75. Lin JH, Wu LS, Tsai KT, Leu SP, Jeang YF, Hsieh MT: "Effects of ginseng on the blood chemistry profile of dexamethasone-treated male rats.", Am J Chin Med, v23, n2, 1995
76. Liu M, Zhang J: "Effects of ginsenoside Rb1 and Rg1 on synaptosomal free calcium level, ATPase and calmodulin in rat hippocampus.", Chin Med J (Engl), v108, n7, Jul 1995
77. Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tono-oka S, Samukawa K, Azuma I: "Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng.", Biol Pharm Bull, v18, n9, Sep 1995
78. Bhattacharya SK, Mitra SK: "Anxiolytic activity of Panax ginseng roots: an experimental study.", J Ethnopharmacol, v34, n1, Aug 1991
79. Wei R, Chen C, Dong J, Qiu S, Cao Z: "[Effect of radix Astragali and radix ginseng in enhancing the metabolism of human myocardial cells in vitro]. [Chinese]", Chung Kuo Chung Yao Tsa Chih, v17, n3, Mar 1992.
80. Matsuda H, Samukawa K, Kubo M: "Anti-hepatitic activity of ginsenoside Ro.", Planta Med, v57, n6, Dec 1991
81. Suzuki Y, Ito Y, Konno C, Furuya T: "[Effects of tissue cultured ginseng on gastric secretion and pepsin activity]. [Japanese]", Yakugaku Zasshi, v111, n12, Dec 1991
82. Kim HS, Jang CG, Lee MK: "Antinarcotic effects of the standardized ginseng extract G115 on morphine.", Planta Med, v56, n2, Apr 1990
83. Takaku T, Kameda K, Matsuura Y, Sekiya K, Okuda H: "Studies on insulin-like substances in Korean red ginseng.", Planta Med, v56, n1, Feb 1990
84. Filaretov AA, Bogdanova TS, Podvigina TT, Bodganov AI: "Role of pituitary-adrenocortical system in b.d. adaptation abilities.", Exp Clin Endocrinol, v92, n2, Dec 1988
85. Kimura Y, Okuda H, Arichi S: "Effects of various ginseng saponins on 5-hydroxytryptamine release and aggregation in human platelets.", J Pharm Pharmacol, v40, n12, Dec 1988
86. Watanabe J, Oh KW, Kim HS, Takahashi M, Kaneto H: "A non-opioid mechanism in the inhibitory effect of ginseng saponins on electrically evoked contractions of guinea-pig ileum and mouse vas deferens.", J Pharmacobiodyn, v11, n6, Jun 1988
87. Hata T, Kita T, Kawabata A, Itoh E, Kawashima Y: "Effect of ginseng-20S-prosapogenin on tissue blood flow measured by the hydrogen clearance method in sympathicotonic- or parasympathicotonic-type stressed mice.", J Pharmacobiodyn, v8, n12, Dec 1985
88. Konno C, Murakami M, Oshima Y, Hikino H: "Isolation and hypoglycemic activity of panaxans Q, R, S, T and U, glycans of Panax ginseng roots", J Ethnopharmacol, v14, n1, Sep 1985
89. Jie YH, Cammisuli S, Baggiolini M: "Immunomodulatory effects of Panax ginseng C. A. Meyer in the mouse", Agents Actions, v15, n3-4, Oct 1984
90. Yamamoto M, Uemura T, Nakama S, Uemiya M, Kumagai A: "Serum HDL-cholesterol-increasing and fatty liver-improving actions of Panax ginseng in high cholesterol diet-fed rats with clinical effect on hyperlipidemia in man.", Am J Chin Med, v11, n1-4, 1983
91. Kimura M, Waki I, Chujo T, Kikuchi T, Hiyama C, Yamazaki K, Tanaka O: "Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas.", J Pharmacobiodyn, v4, n6, Jun 1981
92. Kimura M, Waki I, Tanaka O, Nagai Y, Shibata S: "Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from ginseng radix.", J Pharmacobiodyn, v4, n6, Jun 1981
93. Ota T, Maeda M, Odashima S, "Mechanism of action of ginsenoside Rh2: uptake and metabolism of ginsenoside Rh2 by cultured B16 melanoma cells.", J Pharm Sci, v80, n12, Dec 1991
94. Cui JF, Garle M, Bjorkhem I, Eneroth P: "Determination of aglycones of ginsenosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng.", Scand J Clin Lab Invest, v56, n2, Apr 1996
95. Akagawa G, Abe S, Tansho S, Uchida K, Yamaguchi H: "Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms.", Immunopharmacol Immunotoxicol, v18, n1, Feb 1996
96. Abe S; Tansho S; Ishibashi H; Inagaki N; Komatsu Y; Yamaguchi H: Protective effect of oral administration of a traditional medicine, Juzen-Taiho-To, and its components on lethal Candida albicans infection in immunosuppressed mice. Immunopharmacol Immunotoxicol 1998 Aug;20(3):421-31
97. Song Z, Johansen HK, Faber V, Moser C, Kharazmi A, Rygaard J, Hoiby N, "Ginseng treatment reduces bacterial load and lung pathology in chronic Pseudomonas aeruginosa pneumonia in rats", Antimicrob Agents Chemother, v41, n5, May 1997
98. Song ZJ, Johansen HK, Faber V, Hoiby N, "Ginseng treatment enhances bacterial clearance and decreases lung pathology in athymic rats with chronic P. aeruginosa pneumonia.", APMIS, v105, n6, Jun 1997
99. Yoshimura H, Watanabe K, Ogawa N, "Psychotropic effects of ginseng saponins on agonistic behavior between resident and intruder mice.", Eur J Pharmacol, v146, n2-3, Feb 9 1988
100. Yoshimura H, Watanabe K, Ogawa N, "Acute and chronic effects of ginseng saponins on maternal aggression in mice.", Eur J Pharmacol, v150, n3, Jun 10 1988
101. Bittles AH, Fulder SJ, Grant EC, Nicholls MR, "The effect of ginseng on lifespan and stress responses in mice", Gerontology, v25, n3, 1979
102. Caso Marasco A; Vargas Ruiz R; Salas Villagomez A: Double-blind study of a multivitamin complex supplemented with ginseng extract, Begona Infante C, Drugs Exp Clin Res 1996;22(6):323-9
103. Banerjee U, Izquierdo JA, "Antistress and antifatigue properties of Panax ginseng: comparison with piracetam", Acta Physiol Lat Am, v32, n4, 1982
104. Bahrke M, Morgan W: Evaluation of the ergogenic properties of ginseng. Sports Med. 1994;18:229-248
105. Allen JD; McLung J; Nelson AG; Welsch M: Ginseng supplementation does not enhance healthy young adults'' peak aerobic exercise performance., J Am Coll Nutr 1998 Oct;17(5):462-6
106. D’Angelo L., Grimaldi R, Caravaggi M, Marcoli M, Perucca E, Lecchini S, Frigo GM, Crema A: A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 1986 Apr-May 16:1 15-22,
107. Pieralisi G; Ripari P; Vecchiet L: Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991 May-Jun;13(3):373-82
108. Grandhi A, Mujumdar AM, Patwardhan B, "A comparative pharmacological investigation of Ashwagandha and Ginseng.", J Ethnopharmacol, v44, n3, Dec 1994.
109. Morris AC, Jacobs I, McLellan TM, Klugerman A, Wang LC, Zamecnik J, "No ergogenic effect of ginseng ingestion.", Int J Sport Nutr, v6, n3, Sep 1996.The purpose of this study was to examine the effects of ginseng extract ingestion on physiological responses to intense exercise
110. Kim YC; Kim SR; Markelonis GJ; Oh TH: Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration [published erratum appears in J Neurosci Res 1998 Oct 1;54(1):123], J Neurosci Res 1998 Aug 15;53(4):426-32
111. Zhao R; McDaniel WF: Ginseng improves strategic learning by normal and brain-damaged rats. Neuroreport 1998 May 11;9(7):1619-24
112. Wen TC, Yoshimura H, Matsuda S, Lim JH, Sakanaka M, "Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia.", Acta Neuropathol (Berl), v91, n1, 1996.
113. Nitta H, Matsumoto K, Shimizu M, Ni XH, Watanabe H, "Panax ginseng extract improves the performance of aged Fischer 344 rats in radial maze task but not in operant brightness discrimination task.", Biol Pharm Bull, v18, n9, Sep 1995.
114. Wang A, Cao Y, Wang Y, Zhao R, Liu C, "[Effects of Chinese ginseng root and stem-leaf saponins on learning, memory and biogenic monoamines of brain in rats]. [Chinese]", Chung Kuo Chung Yao Tsa Chih, v20, n8, Aug 1995.
115. Lasarova MB, Mosharrof AH, Petkov VD, Markovska VL, Petkov VV, "Effect of piracetam and of standardized ginseng extract on the electroconvulsive shock-induced memory disturbances in "step-down" passive avoidance.", Acta Physiol Pharmacol Bulg, v13, n2, 1987.
116. Sotaniemi EA, Haapakoski E, Rautio A, "Ginseng therapy in non-insulin-dependent diabetic patients.", Diabetes Care, v18, n10, Oct 1995.
117. Xie ZC, Qian ZK, Liu ZW, "[Effect of ginseng on antiperoxidate injury in myocardium and erythrocytes in streptozocin-induced diabetic rats]. [Chinese]", Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, v13, n5, May 1993.
118. Waki I, Kyo H, Yasuda M, Kimura M, "Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals.", J Pharmacobiodyn, v5, n8, Aug 1982.
119. Zhang JS, Sigdestad CP, Gemmell MA, Grdina DJ, "Modification of radiation response in mice by fractionated extracts of Panax ginseng.", Radiat Res, v112, n1, Oct 1987.
120. Taik-Koo Y, Soo-Yong C. Preventive effect of ginseng intake against various human cancers: a case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev. 1995;4:401-408.)
121. Bespalov VG, Aleksandrov VA, Davydov VV, Limarenko AIu, Molokovskii DS, Petrov AS, Slepian LI, Trilis IaG, "[Inhibition of mammary gland carcinogenesis using a tincture from biomass of ginseng tissue culture]. [Russian]", Biull Eksp Biol Med, v115, n1, Jan 1993.
122. Bespalov VG, Davydov VV, Limarenko AIu, Slepian LI, Aleksandrov VA, "[The inhibition of the development of experimental tumors of the cervix uteri and vagina by using tinctures of the cultured-cell biomass of the ginseng root and its germanium-selective stocks]. [Russian]", Biull Eksp Biol Med, v116, n11, Nov 1993.
123. Tode T, Kikuchi Y, Kita T, Hirata J, Imaizumi E, Nagata I, "Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice.", J Cancer Res Clin Oncol, v120, n1-2, 1993.
124. Kumar R, Grover SK, Divekar HM, Gupta AK, Shyam R, Srivastava KK, "Enhanced thermogenesis in rats by Panax ginseng, multivitamins and minerals.", Int J Biometeorol, v39, n4, Nov 1996.
125. Lee BH; Lee SJ; Hui JH; Lee S; Sung JH; Huh JD; Moon C: In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta Med 1998 Aug;64(6):500-3
126. Chin R. Ginseng and common pregnancy disorders. Asia Oceanica J Obstet Gynecol. 1991;17:379-380
127. Han KH; Choe SC; Kim HS; Sohn DW; Nam KY; Oh BH; Lee MM; Park YB; Choi YS; Seo JD; Lee YW: Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med 1998;26(2):199-209
128. Wang WK; Chen HL; Hsu TL; Wang YY: Alteration of pulse in human subjects by three Chinese herbs., Am J Chin Med 1994;22(2):197-203
129. Kim SH; Jeong KS; Ryu SY; Kim TH: Panax ginseng prevents apoptosis in hair follicles and accelerates recovery of hair medullary cells in irradiated mice in Vivo 1998 Mar-Apr;12(2):219-22
130. Xiaoguang C; Hongyan L; Xiaohong L; Zhaodi F; Yan L; Lihua T; Rui H: Cancer chemopreventive and therapeutic activities of red ginseng., J Ethnopharmacol 1998 Feb;60(1):71-8
131. Nakajima S; Uchiyama Y; Yoshida K; Mizukawa H; Haruki E: The effects of ginseng radix rubra on human vascular endothelial cells Am J Chin Med 1998;26(3-4):365-73
132. See DM, Broumand N, Sahl L, Tilles JG, "In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.", Immunopharmacology, v35, n3, Jan 1997
133. Luo YM, Cheng XJ, Yuan WX, "Effects of ginseng root saponins and ginsenoside Rb1 on immunity in cold water swim stress mice and rats.", Chung Kuo Yao Li Hsueh Pao, v14, n5, Sep 1993.
134. Yeung HW, Cheung K, Leung KN, "Immunopharmacology of Chinese medicine 1, ginseng induced immunosuppression in virus-infected mice.", Am J Chin Med, v10, n1-4, 1982.
135. Cui X; Sakaguchi T; Ishizuka D; Tsukada K; Hatakeyama K: Orally administered ginseng extract reduces serum total cholesterol and triglycerides that induce fatty liver in 66% hepatectomized rats, J Int Med Res 1998 Aug-Sep;26(4):181-7
136. Takahashi M; Tokuyama S: Pharmacological and physiological effects of ginseng on actions induced by opioids and psychostimulants. Methods Find Exp Clin Pharmacol 1998 Jan-Feb;20(1):77-84
137. Kim HS, Kang JG, Rheu HM, Cho DH, Oh KW, "Blockade by ginseng total saponin of the development of methamphetamine reverse tolerance and dopamine receptor supersensitivity in mice.", Planta Med, v61, n1, Feb 1995
138. Lee FC, Ko JH, Park JK, Lee JS, "Effects of Panax ginseng on blood alcohol clearance in man.", Clin Exp Pharmacol Physiol, v14, n6, Jun 1987
139. Scaglione F, Cattaneo G, Alessandria M, Cogo R, "Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected] [published erratum appears in Drugs Exp Clin Res 1996;22(6):338].", Drugs Exp Clin Res, v22, n2, 1996:65-72
140. Salvati G, Genovesi G, Marcellini L, et al: Effects of Panax ginseng C. A. Meyer saponins on male fertility. Panminerva Med. 1996;38:249-254
141. Fahim MS, Fahim Z, Harman JM, Clevenger TE, Mullins W, Hafez ES, "Effect of Panax ginseng on testosterone level and prostate in male rats.", Arch Androl, v8, n4, Jun 1982
142. Choi HK; Seong DH; Rha KH: Clinical efficacy of Korean red ginseng for erectile dysfunction., Int J Impot Res 1995 Sep;7(3):181-6
143. Choi YD; Xin ZC; Choi HK: Effect of Korean red ginseng on the rabbit corpus cavernosal smooth muscle. Int J Impot Res 1998 Mar;10(1):37-43
144. Hopkins MP, Androff L, Benninghoff AS, "Ginseng face cream and unexplained vaginal bleeding.", Am J Obstet Gynecol, v159, n5, Nov 1988
145. Kim C, Choi H, Kim CC, Kim JK, Kim MS, "Influence of ginseng on mating behavior of male rats.", Am J Chin Med, v4, n2, Summer 1976
146. Yoshimura H; Kimura N; Sugiura K: Preventive effects of various ginseng saponins on the development of copulatory disorder induced by prolonged individual housing in male mice. Methods Find Exp Clin Pharmacol 1998 Jan-Feb;20(1):59-64
147. Ding DZ; Shen TK; Cui YZ, Chung Kuo Chung Hsi I Chieh Ho Tsa Chih: Effects of red ginseng on the congestive heart failure and its mechanism, 1995 Jun;15(6):325-7
148. Zhan Y; Xu XH; Jiang YP, Chung Hua I Hsueh Tsa Chih: Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries, 1994 Oct;74(10):626-8, 648
149. Toh HT, "Improved isolated heart contractility and mitochondrial oxidation after chronic treatment with Panax ginseng in rats.", Am J Chin Med, v22, n3-4, 1994.
150. Lee DC, Lee MO, Kim CY, Clifford DH, "Effect of ether, ethanol and aqueous extracts of ginseng on cardiovascular function in dogs.", Can J Comp Med, v45, n2, Apr 1981
151. Zuin M, Battezzati PM, Camisasca M, Riebenfeld D, Podda M, "Effects of a preparation containing a standardized ginseng extract combined with trace elements and multivitamins against hepatotoxin-induced chronic liver disease in the elderly.", J Int Med Res, v15, n5, Sep-Oct 1987.
152. Thommessen B; Laake K: No identifiable effect of ginseng (Gericomplex) as an adjuvant in the treatment of geriatric patients. Aging (Milano), 8(6):417-20 1996 Dec
153. Liang H, Wang Z, Tian F, Geng B, "[Effects of Astragalus polysaccharides and ginsenosides of Ginseng stems and leaves on lymphocytes membrane fluidity and lipid peroxidation in traumatized mice]. [Chinese]", Chung Kuo Chung Yao Tsa Chih, v20, n9, Sep 1995.
154. Zhang WY, Teng H, Zheng Y, "[Ginseng saponin treatment for intrauterine growth retardation]. [Chinese]", Chung Hua I Hsueh Tsa Chih, v74, n10, Oct 1994.
155. Yi RL, Li W, Hao XZ, "[Inductive differentiation effect of ginsenosides on human acute non-lymphocytic leukemic cells in 58 patients]. [Chinese]", Chung Kuo Chung Hsi I Chieh Ho Tsa Chih, v13, n12, Dec 1993.
156. Petkov VD, Cao Y, Todorov I, Lazarova M, Getova D, Stancheva S, Alova L, "Behavioral effects of stem-leaves extract from Panax ginseng C. A. Meyer.", Acta Physiol Pharmacol Bulg, v18, n2, 1992.
157. Sun XB, Matsumoto T, Yamada H, "Purification of an anti-ulcer polysaccharide from the leaves of Panax ginseng.", Planta Med, v58, n5, Oct 1992.
158. Wei BH, "[Treatment of shock with traditional Chinese medicine and Western medicine]. [Review] [23 refs] [Chinese]", Chung Hsi I Chieh Ho Tsa Chih, v2, n4, Oct 1982.
159. McGruffin M. et al: American Herbal Products Association’s Botanical Safety Handbook, CRC Press, 1997, ISBN 0-8493-1675-8
160. Wang S, Zhai S, Wang Y, Wang L, "[Effect of radix Ginseng-faeces Trogopterori combination on pharmacodynamics and effective chemical composition of radix Ginseng]. [Chinese]", Chung Kuo Chung Yao Tsa Chih, v20, n10, Oct 1995
161. Greenspan EM, "Ginseng and vaginal bleeding [letter].", JAMA, v249, n15, Apr 15 1983
162. Miller LG: Herbal Medicinals: Selected Clinical Considerations Focusing on Known or Potential Drug-Herb Interactions.,Arch Intern Med, 1998, Nov 9;158(20):2200-11
163. Siegel R. Ginseng abuse syndrome. JAMA. 1979;241:1614-1615
164. Palmer B, Montgomery A, Monteiro J. Ginseng and mastalgia [letter]. BMJ. 1978;1:1284
165. Chin R. Ginseng and common pregnancy disorders. Asia Oceanica J Obstet Gynecol . 1991;17:379-380.
166. Ding DZ; Shen TK; Cui YZ, Chung Kuo Chung Hsi I Chieh Ho Tsa Chih: Effects of red ginseng on the congestive heart failure and its mechanism, 1995 Jun;15(6):325-7
167. Jones BD, Runikis AM: Interaction of Ginseng with Phenelzine, J. Clin Psychopharmacol, 1987, 7:201-2
168. Shader RI, Greenblatt DJ: Phenelizine and the Dream Machine –Ramblings and Reflections, Clin Psychother, 1985, 5:65
169. Guo GH, Lu YB, Song LF, "[Effects of compatibility of radix Ginseng with faeces Trogopterori on toxicity in experimental animals]. [Chinese]", Chung Kuo Chung Yao Tsa Chih, v19, n4, Apr 1994.
170. Ryu SJ, Chien YY, "Ginseng-associated cerebral arteritis.", Neurology, v45, n4, Apr 1995.
171. Janetzky K, Morreale AP, "Probable interaction between warfarin and ginseng.", Am J Health Syst Pharm, v54, n6, Mar 15 1997.
172. 50 Common Herbs and their potential Interactions, The Pharmacists/Prescriber Letter, Document #130901, 1998, Theraputic Research Center.
173. Kariyone T: Atlas of Medicinal Plants
174. John K Chen, Ph.D. Pharm.D., O.D. L.Ac., 1998, Lotus Herbs, La Puente, CA.
175. Hiai S; Yokoyama H; Oura H; Yano S: Stimulation of pituitary-adrenocortical system by ginseng saponin, Endocrinol Jpn, v26, n6, Dec 1979
176. Engels HJ; Wirth JC: No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal aerobic exercise. J. Am Diet Assoc 1997 Oct;97(10):1110-5

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