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GlucaGen
CLINICAL PHARMACOLOGY
GlucaGen
Intramuscular (im) injection of GlucaGen® resulted in a mean Cmax (CV%) of 1686 pg/ml (43%) and median Tmaxof 12.5 minutes. The mean apparent half-life of 45 minutes after im injection probably reflects prolonged absorption from the injection site. Glucagon is degraded in the liver, kidney, and plasma.'
Antihypoglycemic Action
Glucagon induces liver glycogen breakdown, releasing glucose from the liver. Blood glucose concentration rises within 10 minutes of injection and maximal concentrations are attained at approximately a half hour after injection (see Figure). Hepatic stores of glycogen are necessary for glucagon to produce an antihypoglycemic effect.
Recovery from insulin induced hypoglycemia (mean blood glucose)
after im injection of 1 mg GlucaGen® in Type I diabetic men
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Gastrointestinal Motility Inhibition: Extra hepatic effects of glucagon include relaxation of the smooth muscle of the stomach, duodenum, small bowel, and colon.
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GlucaGen
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