Overdosage of sulfonylureas, including MICRONASE Tablets, can produce hypoglycemia. Mild hypoglycemic symptoms, without loss of con- sciousness or neurological findings, should be treated aggressively with oral glucose and adjust- ments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but con- stitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intra- venous injection of concentrated (50%) glucose solu- tion. This should be followed by a continuous infu- sion of a more dilute (10%) glucose solution at a rate which will maintain the blood glucose at a level above 100 mg/dL. Patients should be closely moni- tored for a minimum of 24 to 48 hours, since hypo- glycemia may recur after apparent clinical recovery.

MICRONASE Tablets are contraindicated in patients with:

1. Known hypersensitivity or allergy to the drug. 2. Diabetic ketoacidosis, with or without coma. This condition should be treated with insulin. 3. Type I diabetes mellitus, as sole therapy.

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