Guaifenesin (glyceryl guaiacolate) has the chemical name 3-(2-methoxyphenoxy)-1,2-propanediol. Its molecular formula is C₁₀H₁₄O₄ with a molecular weight of 198.21. It is a white or slightly gray crystalline substance with a slightly bitter aromatic taste. One gram dissolves in 20 mL water at 25°C; it is freely soluble in ethanol. Guaifenesin is readily absorbed from the GI tract and is rapidly metabolized and excreted in the urine. Guaifenesin has a plasma half-life of one hour. The major urinary metabolite is β-(2-methoxyphenoxy) lactic acid.

ORGANIDIN® NR (guaifenesin) is an expectorant available for oral administration as:

Tablets — each containing 200 mg guaifenesin, USP.

Other ingredients: Corn starch, croscarmel-lose sodium, FD&C Red No. 40, magnesium stearate, microcrystalline cellulose.

Liquid — each teaspoonful (5 mL) containing 100 mg guaifenesin, USP.

Other ingredients: Caramel, citric acid, flavor (raspberry), glycerin, propylene gly-col, purified water, saccharin sodium, sodium benzoate, sorbitol solution.

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