Doxercalciferol, the active ingredient in Hectorol , is a synthetic vitamin D₂analog that undergoes metabolic activation in vivo to form 1a,25-dihydroxyvitamin D₂ (1á,25-(OH)₂D₂), a naturally occurring, biologically active form of vitamin D₂. Hectorol is available as a sterile, clear, essentially colorless to faint yellow, aqueous solution for intravenous injection. Each milliliter (mL) of solution contains doxercalciferol, 2 mcg; Polysorbate 20, 4 mg; sodium chloride, 1.5 mg; sodium ascorbate, 10 mg; sodium phosphate, dibasic, 7.6 mg; sodium phosphate, monobasic, 1.8 mg; and disodium edetate, 1.1 mg.

Doxercalciferol is a colorless crystalline compound with a calculated molecular weight of 412.66 and a molecular formula of C₂₈H₄₄O₂. It is soluble in oils and organic solvents, but is relatively insoluble in water. Chemically, doxercalciferol is (1a,3β,5Z,7E,22E)-9,10-secoergosta- 5,7,10(19),22-tetraene-1,3-diol and has the following structural formula:

Other names frequently used for doxercalciferol are 1a-hydroxyvitamin D₂, 1a-OH-D₂, and 1a-hydroxyergocalciferol.

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