Humulin R (U-500) is especially useful for the treatment of diabetic patients with marked insulin resistance (daily requirements more than 200 units), since a large dose may be administered subcutaneously in a reasonable volume.

Humulin R (U-500) should only be administered subcutaneously. It is inadvisable to inject Humulin R (U-500) intravenously because of possible inadvertent overdosage.

It is recommended that an insulin syringe or tuberculin-type syringe be used for the measurement of dosage. Variations in dosage are frequently possible in the insulin-resistant patient, since the individual is unresponsive to the pharmacologic effect of the insulin. Nevertheless, accuracy of measurement is to be encouraged because of the potential danger of the preparation.

STORAGE

Insulin should be kept in a cold place, preferably in a refrigerator, but must not be frozen.

Do not inject insulin that is not water-clear. Discoloration, turbidity, or unusual viscosity indicates deterioration or contamination.

Use of a package of insulin should not be started after the expiration date stamped on it.

Vials, 500 units/mL, 20 mL (HI-500) (1s), NDC 0002-8501-01

Literature revised April 9, 2007., Eli Lilly and Company, Indianapolis, IN 46285, USA. FDA rev date: 9/10/2007

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