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Hyalgan

Clinical Pharmacology
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Clinical Pharmacology

Hyalgan

 

TABLE 5
ANCOVA of 50-Foot Walk Test (mm) VAS
by Week for All Completed Subjects
 
 Week
 
 3 4 5 9 12 16 21 26
Adjusted Means Hyalgan®
27.23 21.54 19.29 20.04 20.26 20.83 18.44 17.88
      Placebo
32.35 28.57 25.67 24.28 26.66 25.44 24.77 26.73
Hyalgan® versus Placebo
5.13 7.03 6.39 4.24 6.40 4.61 6.33 8.846
p-value
0.06 0.01 0.01 0.1 0.03 0.1 0.02 0.004

 

TABLE 7 Subjects' Categorical Assessments of Pain for Completed Subjects in Prior 48 Hours: Level of Pain by Treatment Group at Baseline and Week 26
TABLE 6
Masked Evaluators' Categorical Assessments of Pain
for Completed Subjects in Prior 48 Hours:
Level of Pain by Treatment Group
at Baseline and Week 26
  NUMBER (%) OF SUBJECTS IN CATEGORY
  Hyalgan® Placebo Naproxen
  Baseline Week 26 Baseline Week 26 Baseline Week 26
None (0)
0 (0.0) 27 (25.7) 0 (0.0) 15 (13.0) 0 (0.0) 17 (15.0)
Slight (1)
1 (1.0) 23 (21.9) 0 (0.0) 27 (23.5) 0 (0.0) 32 (28.3)
Mild (2)
2 (1.9) 24 (22.9) 2 (1.7) 29 (25.2) 2 (1.8) 27 (23.9)
Moderate (3)
69 (65.7) 26 (24.8) 85 (73.9) 34 (29.6) 79 (70.5) 28 (24.8)
Marked (4)
33 (31.4) 5 (4.8) 28 (24.3) 10 (8.7) 31 (27.7) 9 (8.0)
TOTAL
105 (100) 105 (100) 115 (100) 115 (100) 112 * (100) 113 (100)
* One Naproxen treated subject was missing a Baseline assessment.
Brand Name: Hyalgan
Generic Name: Hyaluronate

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