DIRECTIONS FOR USE

Hyalgan® is administered by intra-articular injection. A treatment cycle consists of five injections given at weekly intervals. Some patients may experience benefit with three injections given at weekly intervals. This has been noted in studies reported in the literature in which patients treated with three injections were followed for 60 days.

Precaution:   Do not use Hyalgan® if the package is opened or damaged. Store in the original packaging (protected from light) below 77° F (25° C). DO NOT FREEZE.

Precaution:   Strict aseptic administration technique must be followed.

Warning:   Do not concomitantly use disinfectants containing quaternary ammonium salts for skin preparation because hyaluronic acid can precipitate in their presence.

Inject subcutaneous lidocaine or similar local anesthetic prior to injection of Hyalgan®.

Precaution:   Remove joint effusion, if present, before injection of Hyalgan®.

Do not use the same syringe for removing joint effusion and for injecting Hyalgan®.

Take care to remove the tip cap of the syringe and needle aseptically.

Inject Hyalgan® into the joint through a 20-gauge needle.

Precaution:   The vial/syringe is intended for single use. The contents of the vial must be used immediately once the container has been opened. Discard any unused Hyalgan®. Inject the full 2 mL in one knee only. If treatment is bilateral, a separate vial should be used for each knee.

• Provide patients with a copy of the Patient Information prior to use.
• Transient pain and/or swelling of the injected joint may occur after intra-articular injection of Hyalgan®.
• As with any invasive joint procedure, it is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection.

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