HYLENEX recombinant is a purified preparation of the enzyme recombinant human hyaluronidase. HYLENEX recombinant is produced by genetically engineered Chinese Hamster Ovary (CHO) cells containing a DNA plasmid encoding for a soluble fragment of human hyaluronidase (PH20). The purified hyaluronidase glycoprotein contains 447 amino acids with an approximate molecular weight of 61,000 Daltons.

HYLENEX recombinant (hyaluronidase human injection) is supplied as a sterile, clear, colorless, nonpreserved, ready for use solution. Each mL contains 150 USP units of recombinant human hyaluronidase per mL with 8.5 mg sodium chloride, 1.8 mg sodium phosphate dibasic dihydrate, 4.2 mg sodium hydroxide, 1.0 mg human serum albumin, 1.0 mg edetate disodium dihydrate, and 0.4 mg calcium chloride dihydrate.

HYLENEX recombinant has an approximate pH of 7.4 and an osmolality of 290 to 350 mOsm.

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