N

58

58

48

38

23

21

20

16

13

Mean (SD)

2.8 (1.8)

8.0 (2.2)

5.8 (1.5)

5.5 (1.8)

4.7 (1.6)

4.7 (1.6)

4.8 (1.5)

4.6 (1.5)

4.3 (1.1)

Mean (SD) for change from pre-Tx

+5.2 (2.6)

+2.9 (2.4)

+2.3 (2.4)

+1.5 (2.2)

+1.5 (1.8)

+1.5 (1.7)

+1.0 (2.1)

+0.7 (2.5)

P-value for change from pre-Tx [1]

<0.0001

<0.0001

<0.0001

0.0045

0.0015

0.0009

0.0897

0.3059

Height Velocity SDS

N

58

58

47

37

22

19

18

15

11

Mean (SD)

-3.3 (1.7)

1.9 (3.0)

-0.2 (1.6)

-0.2 (2.0)

-0.7 (2.1)

-0.6 (2.1)

-0.4 (1.4)

-0.4 (1.9)

-0.4 (1.9)

Mean (SD) for change from pre-Tx

+5.2 (3.1)

+3.1 (2.3)

+2.9 (2.3)

+2.2 (2.2)

+2.5 (2.2)

+2.7 (1.7)

+2.5 (2.1)

+2.7 (2.8)

Height SDS

N

61

61

51

40

24

21

20

16

13

Mean (SD)

-6.7 (1.8)

-5.9 (1.8)

-5.6 (1.8)

-5.4 (1.8)

-5.5 (1.9)

-5.6 (1.8)

-5.4 (1.8)

-5.2 (2.0)

-5.2 (2.0)

Mean (SD) for change from pre-Tx

+0.8 (0.5)

+1.2 (0.8)

+1.4 (1.1)

+1.3 (1.2)

+1.4 (1.3)

+1.4 (1.2)

+1.4 (1.1)

+1.5 (1.1)

Pre-Tx = Pre-treatment; SD = Standard Deviation; SDS = Standard Deviation Score
[1] P-values for comparison versus pre-Tx values are computed using paired t-tests.

Forty-nine subjects were included in an analysis of the effects of INCRELEX on bone age advancement. The mean ± SD change in chronological age was 4.9 ± 3.4 years and the mean ± SD change in bone age was 5.3 ± 3.4 years.