Iplex
OVERDOSE
There were no instances of overdosage with IPLEXÃ? in the Primary IGFD clinical trial. Based on the known pharmacological effects of IGF-1, acute overdosage could lead to hypoglycemia. Treatment of acute overdosage of IPLEXÃ? should be directed at reversing hypoglycemia. Mild hypoglycemia can usually be treated with oral glucose or food. If the overdose results in loss of consciousness, treatment with parenteral glucagon or intravenous glucose may be required.
Long-term overdosage could result in signs and/or symptoms of acromegaly.
CONTRAINDICATIONS
IPLEXÃ? (mecasermin rinfabate [rDNA origin] injection) should not be used for growth promotion in patients with closed epiphyses.
IPLEXÃ? is contraindicated in the presence of active or suspected neoplasia, and therapy should be discontinued when there is any evidence of active neoplasia.
IPLEXÃ? is contraindicated in patients allergic to mecasermin rinfabate (rhIGF-1/rhIGFBP-3) or any of the excipients in IPLEXÃ?.
Intravenous administration of IPLEXÃ? is contraindicated.
Generic Name: Mecasermin Rinfabate [rDNA origin] Injection
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