The active ingredient in ATROVENT HFA Inhalation Aerosol is ipratropium bromide. It is an anticholinergic bronchodilator chemically described as 8-Azoniabicyclo [3.2.1] octane, 3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-, bromide, monohydrate, (endo, syn ): a synthetic quaternary ammonium compound, chemically related to atropine. The structural formula for ipratropium bromide is:

C₂₀H₃₀BrNO₃•H₂O     ipratropium bromide     Mol. Wt. 430.4

Ipratropium bromide is a white to off-white crystalline substance, freely soluble in water and methanol and sparingly soluble in ethanol and insoluble in lipophilic solvents such as ether, chloroform, and fluorocarbons.

ATROVENT HFA Inhalation Aerosol is a pressurized metered-dose aerosol unit for oral inhalation that contains a solution of ipratropium bromide. The net weight of each canister is 12.9 grams and provides 200 inhalations. After priming, each actuation of the inhaler delivers 21 mcg of ipratropium bromide from the valve in 56 mg of solution and delivers 17 mcg of ipratropium bromide from the mouthpiece. The actual amount of drug delivered to the lung may depend on patient factors, such as the coordination between the actuation of the device and inspiration through the delivery system. The excipients are HFA-134a (1,1,1,2-tetrafluoroethane) as propellant, purified water, dehydrated alcohol, and anhydrous citric acid. This product does not contain chlorofluorocarbons (CFCs) as a propellant.

Atrovent® HFA (ipratropium bromide HFA) Inhalation Aerosol should be primed before using for the first time by releasing 2 test sprays into the air away from the face. In cases where the inhaler has not been used for more than 3 days, prime the inhaler again by releasing 2 test sprays into the air away from the face.

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